Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 18/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 8/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.43 |
| ▸ | RBP4 | P02753 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15106092 | 1.00 | DPP4 (0.46) | DPP4DPP7DPP8DPP9RBP4 | |
| SCHEMBL52331 | 1.00 | DPP4 (0.46) | DPP4DPP7DPP8DPP9RBP4 | |
| SCHEMBL15114461 | 0.85 | RBP4 (0.43) | DPP4DPP7DPP8DPP9RBP4 | |
| SCHEMBL2896968 | 0.83 | — | — | |
| SCHEMBL12474752 | 0.83 | — | — | |
| SCHEMBL2894448 | 0.83 | — | — | |
| SCHEMBL15116680 | 0.82 | DPP4 (0.45) | DPP4DPP7DPP8DPP9KCNH2 | |
| Hydrochloric Acid SCHEMBL25295815 | 0.81 | DPP4 (0.46) | DPP4DPP7DPP8DPP9NAMPT | |
| Hydrochloric Acid SCHEMBL25295814 | 0.81 | DPP4 (0.46) | DPP4DPP7DPP8DPP9NAMPT | |
| SCHEMBL27675943 | 0.80 | DPP4 (0.48) | DPP4DPP7DPP8DPP9NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280981-B1 | BRIDGED HETEROCYCLES AS HIV INTEGRASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2014-04-23 | — | — | EP | disclosed |
| US-8129398-B2 | HIV integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-06 | — | — | US | disclosed |
| CN-102036996-A | Bridged heterocycles as HIV integrase inhibitors | BRISTOL MYERS SQUIBB CO | 2011-04-27 | — | — | CN | disclosed |
| US-20090253677-A1 | HIV Integrase Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253677-A1 | HIV Integrase Inhibitors | DNTT, POLB, UNG | DPP4 1850/4885DPP7 1603/4885DPP8 1374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.