Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8959389 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL7523995 | 0.87 | — | — | |
| SCHEMBL3197391 | 0.71 | — | — | |
| SCHEMBL518033 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL8767180 | 0.71 | CYP3A4 (0.33) | — | |
| SCHEMBL29368502 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL15216 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL10947471 | 0.71 | CYP3A4 (0.33) | — | |
| Hydrochloric Acid SCHEMBL119032 | 0.71 | — | — | |
| SCHEMBL4537289 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487839-B8 | METHODS FOR PRODUCING NORGALANTHAMINE, AS WELL AS ISOMERS, SALTS AND HYDRATES THEREOF | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2007-06-13 | — | — | EP | disclosed |
| EP-1487839-B1 | METHODS FOR PRODUCING NORGALANTHAMINE, AS WELL AS ISOMERS, SALTS AND HYDRATES THEREOF | SANOCHEMIA PHARMAZEUTICA AG (AT) | 2007-04-18 | — | — | EP | disclosed |
| EP-1681291-A1 | Process for the preparation of norgalanthamine, its isomers, salts and hydrates | Sanochemia Pharmazeutika Aktiengesellschaft (AT) | 2006-07-19 | — | — | EP | disclosed |
| EP-1487839-A1 | METHODS FOR PRODUCING NORGALANTHAMINE, AS WELL AS ISOMERS, SALTS AND HYDRATES THEREOF | Sanochemia Pharmazeutica Aktiengesellschaft (AT) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003080623-A1 | METHODS FOR PRODUCING NORGALANTHAMINE, AS WELL AS ISOMERS, SALTS AND HYDRATES THEREOF | SANOCHEMIA PHARMAZEUTIKA AKTIENGESELLSCHAFT (AT) | 2003-10-02 | — | — | WO | disclosed |