Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 2/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5235216 | 1.00 | KDR (0.44) | KDRCNR2FLT1MGLLTACR1 | |
| SCHEMBL5233927 | 0.90 | KDR (0.38) | KDRCNR2FLT1TACR1DGAT2 | |
| SCHEMBL5233924 | 0.90 | KDR (0.38) | KDRCNR2FLT1TACR1DGAT2 | |
| SCHEMBL5239591 | 0.88 | AR (0.39) | KDRGAARAB9ALMNADRD2 | |
| SCHEMBL5239587 | 0.88 | AR (0.39) | KDRGAARAB9ALMNADRD2 | |
| SCHEMBL5238033 | 0.86 | MGLL (0.41) | KDRMGLLPOLBCYP1A2BRAF | |
| SCHEMBL5238037 | 0.86 | MGLL (0.41) | KDRMGLLPOLBCYP1A2BRAF | |
| SCHEMBL5240230 | 0.86 | CYP1A2 (0.45) | TACR1GAARAB9ALMNAPOLB | |
| SCHEMBL5240236 | 0.86 | CYP1A2 (0.45) | TACR1GAARAB9ALMNAPOLB | |
| SCHEMBL5238619 | 0.85 | KDR (0.35) | KDRMGLLTACR1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |