Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 10/20 | 1.00 |
| ▸ | AVPR1A | P37288 | 7/20 | 1.00 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236931 | 0.85 | AVPR1A (1.00) | AVPR2AVPR1AAVPR1B | |
| SCHEMBL8820431 | 0.85 | AVPR2 (0.74) | AVPR2AVPR1ARAB9AHSD11B1 | |
| SCHEMBL6990759 | 0.81 | AVPR1A (0.68) | AVPR2AVPR1AAVPR1BHSD11B1 | |
| SCHEMBL5231630 | 0.79 | AVPR2 (0.67) | AVPR2AVPR1AAVPR1BRAB9AALDH1A1 | |
| SCHEMBL7319409 | 0.78 | AVPR2 (0.66) | AVPR2AVPR1ARAB9AALDH1A1 | |
| SCHEMBL6988983 | 0.77 | AVPR1A (0.79) | AVPR2AVPR1AAVPR1BHSD11B1 | |
| SCHEMBL8820498 | 0.77 | AVPR2 (0.63) | AVPR2AVPR1A | |
| SCHEMBL8820731 | 0.76 | AVPR1A (0.63) | AVPR2AVPR1AAVPR1B | |
| SCHEMBL8820748 | 0.76 | AVPR2 (0.61) | AVPR2AVPR1A | |
| SCHEMBL8820429 | 0.75 | AVPR1A (0.69) | AVPR2AVPR1AAVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996022295-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | claimed |
| US-5532235-A | TO TREAT EXCESS RENAL REABSORPTION | AMERICAN CYANAMID COMPANY (US) | 1996-07-02 | — | — | US | claimed |
| EP-0804440-B1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-1996022295-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5532235-A | TO TREAT EXCESS RENAL REABSORPTION | AMERICAN CYANAMID COMPANY (US) | 1996-07-02 | — | — | US | disclosed |