Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 6/20 | 0.66 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.66 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559724 | 0.81 | AVPR2 (0.51) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL5231630 | 0.80 | AVPR2 (0.67) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL5236931 | 0.80 | AVPR1A (1.00) | AVPR2AVPR1A | |
| SCHEMBL5235682 | 0.78 | AVPR2 (1.00) | AVPR2AVPR1ARAB9AALDH1A1 | |
| SCHEMBL5236545 | 0.77 | AVPR2 (0.44) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL5233013 | 0.75 | AVPR2 (0.64) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL5239857 | 0.73 | AVPR1A (0.52) | AVPR2AVPR1AHPGDKMT2AALDH1A1 | |
| SCHEMBL8820844 | 0.72 | AVPR2 (0.54) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL5236488 | 0.71 | AVPR2 (0.49) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL19454364 | 0.70 | ALDH1A1 (0.45) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996022295-A9 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | — | 1996-11-14 | — | — | WO | disclosed |
| WO-1996022295-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5532235-A | TO TREAT EXCESS RENAL REABSORPTION | AMERICAN CYANAMID COMPANY (US) | 1996-07-02 | — | — | US | disclosed |