Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.53 |
| ▸ | MMP2 | P08253 | 3/20 | 0.52 |
| ▸ | MMP8 | P22894 | 3/20 | 0.52 |
| ▸ | MMP12 | P39900 | 3/20 | 0.52 |
| ▸ | MMP13 | P45452 | 3/20 | 0.52 |
| ▸ | MMP14 | P50281 | 3/20 | 0.52 |
| ▸ | MMP16 | P51512 | 3/20 | 0.52 |
| ▸ | MMP9 | P14780 | 2/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP3 | P08254 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3738351 | 0.87 | HSD17B10 (0.64) | HSD17B10MMP2MMP8MMP12MMP13 | |
| SCHEMBL3735319 | 0.83 | HSD17B10 (0.59) | HSD17B10MMP2MMP8MMP12MMP13 | |
| SCHEMBL9890648 | 0.83 | HSD17B10 (0.62) | HSD17B10MMP2MMP8MMP12MMP13 | |
| SCHEMBL3736235 | 0.82 | HSD17B10 (0.57) | HSD17B10PTGS1SMN1; SMN2KDM4ELCK | |
| SCHEMBL3738751 | 0.80 | HSD17B10 (0.57) | HSD17B10MMP2MMP12MMP9PTGS1 | |
| SCHEMBL8603589 | 0.79 | PTGDR2 (0.57) | PTGS2MMP2MMP8MMP12MMP13 | |
| SCHEMBL3740107 | 0.78 | CYP1A2 (0.51) | HSD17B10MMP2MMP8MMP12MMP13 | |
| SCHEMBL11889771 | 0.77 | HSD17B10 (0.55) | HSD17B10MMP2MMP8MMP12MMP13 | |
| SCHEMBL3749551 | 0.77 | HSD17B10 (0.54) | HSD17B10PTGS2MMP2MMP8MMP12 | |
| SCHEMBL15703754 | 0.77 | MEN1 (0.55) | HSD17B10MMP2MMP8MMP12MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817031-A1 | NOVEL SPECIFIC CASPASE-10 INHIBITORS | Merck Patent GmbH (DE) | 2007-08-15 | — | — | EP | claimed |
| WO-2006058592-A1 | NOVEL SPECIFIC CASPASE-10 INHIBITORS | MERCK PATENT GMBH (DE) | 2006-06-08 | — | — | WO | claimed |