Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 14/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 14/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5231258 | 0.92 | HCRTR1 (0.47) | HCRTR1HCRTR2SMN1; SMN2POLBSIGMAR1 | |
| SCHEMBL5236794 | 0.91 | POLB (0.41) | HCRTR1HCRTR2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5236182 | 0.91 | POLB (0.46) | HCRTR1HCRTR2HPGDSMN1; SMN2NPC1 | |
| SCHEMBL5233648 | 0.89 | HCRTR1 (0.42) | HCRTR1HCRTR2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5236894 | 0.88 | HCRTR1 (0.38) | HCRTR1HCRTR2NPC1RAB9APOLB | |
| SCHEMBL5235749 | 0.88 | POLB (0.42) | HCRTR1HCRTR2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5237472 | 0.88 | POLB (0.39) | HCRTR1HCRTR2NPC1RAB9APOLB | |
| SCHEMBL5239914 | 0.87 | HCRTR1 (0.42) | HCRTR1HCRTR2NPC1RAB9APOLB | |
| SCHEMBL5236986 | 0.87 | NPC1 (0.41) | HCRTR1HCRTR2HPGDNPC1RAB9A | |
| SCHEMBL5234748 | 0.87 | KMT2A (0.38) | HCRTR1HCRTR2NPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |