Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234748 | 0.95 | KMT2A (0.38) | NPC1RAB9AHCRTR1HCRTR2POLB | |
| SCHEMBL5236182 | 0.93 | POLB (0.46) | NPC1RAB9AHCRTR1HCRTR2POLB | |
| SCHEMBL5236794 | 0.91 | POLB (0.41) | NPC1RAB9AHCRTR1HCRTR2POLB | |
| SCHEMBL5233648 | 0.91 | HCRTR1 (0.42) | NPC1RAB9AHCRTR1HCRTR2POLB | |
| SCHEMBL5230652 | 0.90 | NAMPT (0.42) | NPC1RAB9AHCRTR1HCRTR2LIPG | |
| SCHEMBL5240254 | 0.90 | NPC1 (0.46) | NPC1RAB9AHCRTR1HCRTR2POLB | |
| SCHEMBL5230093 | 0.89 | HCRTR1 (0.39) | NPC1RAB9AHCRTR1HCRTR2POLB | |
| SCHEMBL5239318 | 0.88 | NPC1 (0.43) | NPC1RAB9AHCRTR1HCRTR2POLB | |
| SCHEMBL5235749 | 0.88 | POLB (0.42) | NPC1RAB9AHCRTR1HCRTR2POLB | |
| SCHEMBL5236424 | 0.87 | HCRTR1 (0.43) | NPC1RAB9AHCRTR1HCRTR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |