Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 15/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5235879 | 0.98 | HTR1A (0.43) | HTR1AADRA1DADRA1AADRA1BSLC6A4 | |
| SCHEMBL5233980 | 0.86 | HTR1A (0.51) | HTR1ASLC6A4CYP3A4CYP2C8DRD2 | |
| SCHEMBL5237796 | 0.86 | HTR1A (0.51) | HTR1ASLC6A4CYP3A4CYP2C8DRD2 | |
| SCHEMBL5239496 | 0.85 | HTR1A (0.51) | HTR1ASLC6A4CYP3A4CYP2C8DRD2 | |
| SCHEMBL5233259 | 0.84 | HTR1A (0.44) | HTR1ASLC6A4CYP3A4CYP2C8DRD2 | |
| SCHEMBL5237265 | 0.83 | HTR1A (0.52) | HTR1ASLC6A4CYP3A4CYP2C8DRD2 | |
| SCHEMBL5237987 | 0.83 | HTR1A (0.52) | HTR1ASLC6A4CYP3A4CYP2C8DRD2 | |
| SCHEMBL4778919 | 0.78 | HTR1A (0.47) | HTR1ASLC6A4CYP3A4CYP2C8DRD2 | |
| SCHEMBL14164014 | 0.78 | HTR1A (0.48) | HTR1ASLC6A4CYP3A4CYP2C8DRD2 | |
| SCHEMBL4782511 | 0.77 | HTR1A (0.48) | HTR1ASLC6A4CYP3A4CYP2C8DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537122-B9 | ANTIDEPRESSANT INDOLEALKYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXAN METHYLAMINES | WYETH CORP (US) | 2007-10-31 | — | — | EP | claimed |
| EP-1537122-B1 | ANTIDEPRESSANT INDOLEALKYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXAN METHYLAMINES | WYETH CORP (US) | 2007-08-22 | — | — | EP | claimed |