Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.58 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5233032 | 0.97 | SHMT2 (0.60) | HRH3SHMT2ALDH1A1MEN1HPGD | |
| SCHEMBL4388156 | 0.90 | HRH3 (0.64) | HRH3ALDH1A1KMT2APOLBKDM4E | |
| SCHEMBL4379469 | 0.90 | HRH3 (0.64) | HRH3SHMT2ALDH1A1KMT2AKDM4E | |
| SCHEMBL14190992 | 0.89 | HRH3 (0.61) | HRH3SHMT2ALDH1A1KMT2APOLB | |
| Hydrochloric Acid SCHEMBL4384339 | 0.89 | HRH3 (0.65) | HRH3ALDH1A1KMT2APOLBKDM4E | |
| Hydrochloric Acid SCHEMBL4377733 | 0.89 | HRH3 (0.65) | HRH3SHMT2ALDH1A1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL4382886 | 0.88 | HRH3 (0.61) | HRH3SHMT2ALDH1A1KMT2APOLB | |
| SCHEMBL4375706 | 0.88 | HRH3 (0.62) | HRH3ALDH1A1POLBKDM4ETDP1 | |
| SCHEMBL5235270 | 0.88 | HRH3 (0.59) | HRH3SHMT2ALDH1A1MEN1HPGD | |
| SCHEMBL5233892 | 0.88 | HRH3 (0.59) | HRH3SHMT2ALDH1A1MEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186721-B2 | Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines | NOVO NORDISK A/S (DK) | 2007-03-06 | — | — | US | claimed |
| US-20050267116-A1 | Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines | HIGH POINT PHARMACEUTICALS, LLC | 2005-12-01 | — | — | US | claimed |
| EP-1513842-B1 | SUBSTITUTED HEXAHYDROPYRROLO (1,2-A)PYRAZINES, OCTAHYDROPYRIDO(1,2-A)PYRAZINES AND DECAHYDROPYRAZINO(1,2-A)AZEPINES | NOVO NORDISK AS (DK) | 2007-03-07 | — | — | EP | disclosed |
| EP-1513842-B1 | SUBSTITUTED HEXAHYDROPYRROLO (1,2-A)PYRAZINES, OCTAHYDROPYRIDO(1,2-A)PYRAZINES AND DECAHYDROPYRAZINO(1,2-A)AZEPINES | NOVO NORDISK AS (DK) | 2007-03-07 | — | — | EP | disclosed |
| US-7186721-B2 | Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines | NOVO NORDISK A/S (DK) | 2007-03-06 | — | — | US | disclosed |
| US-7186721-B2 | Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines | NOVO NORDISK A/S (DK) | 2007-03-06 | — | — | US | disclosed |
| US-7186721-B2 | Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines | NOVO NORDISK A/S (DK) | 2007-03-06 | — | — | US | disclosed |
| US-20050267116-A1 | Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines | HIGH POINT PHARMACEUTICALS, LLC | 2005-12-01 | — | — | US | disclosed |
| US-6906060-B2 | Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines | NOVO NORDISK A/S (DK) | 2005-06-14 | — | — | US | disclosed |
| EP-1513842-A1 | SUBSTITUTED HEXAHYDROPYRROLO (1,2-A)PYRAZINES, OCTAHYDROPYRIDO(1,2-A)PYRAZINES AND DECAHYDROPYRAZINO(1,2-A)AZEPINES | NOVO NORDISK A/S (DK) | 2005-03-16 | — | — | EP | disclosed |
| US-20040023946-A1 | Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines | VTVX HOLDINGS II LLC | 2004-02-05 | — | — | US | disclosed |
| WO-2003104235-A1 | SUBSTITUTED HEXAHYDROPYRROLO[1,2-A]PYRAZINES, OCTAHYDROPYRIDO[1,2-A]PYRAZINES AND DECAHYDROPYRAZINO[1,2-A]AZEPINES | NOVO NORDISK A/S (DK) | 2003-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040023946-A1 | Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines | HRH2, HRH4, HRH1 | HRH3 4/4885SHMT2 3517/4885ALDH1A1 835/4885 |
| US-20050267116-A1 | Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines | HRH2, HRH4, HRH1 | HRH3 4/4885SHMT2 3969/4885ALDH1A1 1228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.