Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 3/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | F12 | P00748 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28197980 | 0.97 | KLK5 (0.47) | KLK5CYP2A6TRPA1CNR2FFAR1 | |
| SCHEMBL4353465 | 0.86 | KLK5 (0.51) | KLK5CYP2A6TRPA1CNR2FFAR1 | |
| SCHEMBL27220785 | 0.84 | KLK5 (0.53) | KLK5CYP2A6TRPA1CNR2FFAR1 | |
| SCHEMBL761986 | 0.84 | KLK5 (0.50) | KLK5CYP2A6TRPA1CNR2FFAR1 | |
| SCHEMBL5716801 | 0.83 | KLK5 (0.49) | KLK5CYP2A6TRPA1CNR2FFAR1 | |
| SCHEMBL2230387 | 0.83 | KLK5 (0.49) | KLK5CYP2A6TRPA1CNR2FFAR1 | |
| SCHEMBL28198079 | 0.83 | KLK5 (0.49) | KLK5CYP2A6TRPA1CNR2FFAR1 | |
| SCHEMBL27597715 | 0.82 | KLK5 (0.46) | KLK5CYP2A6TRPA1CNR2FFAR1 | |
| SCHEMBL231952 | 0.81 | KLK5 (0.51) | KLK5CYP2A6TRPA1CNR2FFAR1 | |
| SCHEMBL9974146 | 0.80 | ACACB (0.47) | KLK5CYP2A6TRPA1CNR2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104761494-B | A kind of preparation method of (S) or (R) 1 (4 methoxy-benzyl) 1,2,3,4,5,6,7,8 octahydro isoquinolin | 上海医药工业研究院 | 2018-01-19 | — | — | CN | claimed |
| CN-117229209-A | Synthetic method of isoquinoline-1, 3 (2H, 4H) -dione derivative | 浙江工业大学 | 2023-12-15 | — | — | CN | disclosed |
| US-11229637-B2 | Nitrogen-containing heteroaryl compounds and methods of use thereof | FIBROGEN, INC. (US) | 2022-01-25 | — | — | US | disclosed |
| CN-113880063-A | Aluminum removing method for ferrophosphorus slag after lithium extraction of waste lithium iron phosphate and preparation method of battery-grade ferric phosphate | 广东光华科技股份有限公司 | 2022-01-04 | — | — | CN | disclosed |
| US-20210060000-A1 | NOVEL NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | FIBROGEN, INC. | 2021-03-04 | — | — | US | disclosed |
| US-10646482-B2 | Nitrogen-containing heteroaryl compounds and methods of use thereof | FIBROGEN, INC. (US) | 2020-05-12 | — | — | US | disclosed |
| US-20190240213-A1 | NOVEL NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | FIBROGEN, INC. | 2019-08-08 | — | — | US | disclosed |
| US-10092558-B2 | Nitrogen-containing heteroaryl compounds and methods of use thereof | FIBROGEN, INC. (US) | 2018-10-09 | — | — | US | disclosed |
| CN-104761494-B | A kind of preparation method of (S) or (R) 1 (4 methoxy-benzyl) 1,2,3,4,5,6,7,8 octahydro isoquinolin | 上海医药工业研究院 | 2018-01-19 | — | — | CN | disclosed |
| CN-104761494-B | A kind of preparation method of (S) or (R) 1 (4 methoxy-benzyl) 1,2,3,4,5,6,7,8 octahydro isoquinolin | 上海医药工业研究院 | 2018-01-19 | — | — | CN | disclosed |
| EP-1330460-A2 | BENZOXAZINONE DERIVATIVES, THEIR PREPARATION AND USE | SMITHKLINE BEECHAM PLC (GB) | 2003-07-30 | — | — | EP | disclosed |
| WO-2002034754-A2 | BENZOXAZINONE DERIVATIVES, THEIR PREPARATION AND USE | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-05-02 | — | — | WO | disclosed |
| US-5189044-A | For treatment of diabetes complications | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-02-23 | — | — | US | disclosed |
| US-4983613-A | Acetamides; treatment of neuropathy, nephropathy, retinopathy or cataracts in diabetic mammals | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-08 | — | — | US | disclosed |
| US-4983613-A | Acetamides; treatment of neuropathy, nephropathy, retinopathy or cataracts in diabetic mammals | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-08 | — | — | US | disclosed |
| EP-0030861-B1 | ISOQUINOLINE ACETIC ACIDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER INC. (US) | 1983-07-27 | — | — | EP | disclosed |
| US-4283539-A | TREATMENT OF DIABETIC CATARACTS | PFIZER INC. (US) | 1981-08-11 | — | — | US | disclosed |
| US-4283539-A | TREATMENT OF DIABETIC CATARACTS | PFIZER INC. (US) | 1981-08-11 | — | — | US | disclosed |
| EP-0030861-A2 | Isoquinoline acetic acids and pharmaceutical compositions thereof | PFIZER INC. (US) | 1981-06-24 | — | — | EP | disclosed |
| EP-0030861-A2 | Isoquinoline acetic acids and pharmaceutical compositions thereof | PFIZER INC. (US) | 1981-06-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11229637-B2 | Nitrogen-containing heteroaryl compounds and methods of use thereof | HIF1AN, HIF1A, EGLN2 | KLK5 4522/4885CYP2A6 1755/4885TRPA1 4735/4885 |
| US-10646482-B2 | Nitrogen-containing heteroaryl compounds and methods of use thereof | HIF1AN, HIF1A, EGLN2 | KLK5 4522/4885CYP2A6 1755/4885TRPA1 4735/4885 |
| US-20190240213-A1 | NOVEL NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | HIF1AN, EGLN3, EGLN2 | KLK5 4514/4885CYP2A6 2356/4885TRPA1 4859/4885 |
| US-10092558-B2 | Nitrogen-containing heteroaryl compounds and methods of use thereof | HIF1AN, HIF1A, EGLN2 | KLK5 4522/4885CYP2A6 1755/4885TRPA1 4735/4885 |
| US-20210060000-A1 | NOVEL NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | HIF1AN, EGLN2, HIF1A | KLK5 4586/4885CYP2A6 2209/4885TRPA1 4851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.