Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | F12 | P00748 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28198079 | 0.98 | KLK5 (0.49) | KLK5NCOA3LMNAFFAR1TRPA1 | |
| SCHEMBL4353465 | 0.87 | KLK5 (0.51) | KLK5NCOA3LMNAFFAR1TRPA1 | |
| SCHEMBL27220785 | 0.86 | KLK5 (0.53) | KLK5NCOA3LMNAFFAR1TRPA1 | |
| SCHEMBL28855596 | 0.85 | KLK5 (0.47) | KLK5NCOA3LMNAFFAR1TRPA1 | |
| SCHEMBL2230387 | 0.84 | KLK5 (0.49) | KLK5NCOA3LMNAFFAR1TRPA1 | |
| SCHEMBL523707 | 0.84 | KLK5 (0.49) | KLK5NCOA3LMNAFFAR1TRPA1 | |
| SCHEMBL5716801 | 0.84 | KLK5 (0.49) | KLK5NCOA3LMNAFFAR1TRPA1 | |
| SCHEMBL231952 | 0.83 | KLK5 (0.51) | KLK5NCOA3LMNAFFAR1TRPA1 | |
| SCHEMBL28197980 | 0.81 | KLK5 (0.47) | KLK5NCOA3LMNAFFAR1TRPA1 | |
| SCHEMBL6859491 | 0.80 | CNR2 (0.52) | KLK5NCOA3LMNAFFAR1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1429768-B1 | NOVEL MEDICAMENTS FOR INHALATION | BOEHRINGER INGELHEIM PHARMA (DE) | 2016-11-16 | — | — | EP | claimed |
| EP-2554539-B1 | Method for producing gamma-spirolactams from cyclic unsaturated carboxylic acids | UNIVERSITÄT POTSDAM (DE) | 2014-12-10 | — | — | EP | claimed |
| EP-2318367-B1 | PIPERIDINE AND PYRROLIDINE COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-03-20 | — | — | EP | claimed |
| EP-2554539-A1 | Method for producing gamma-spirolactams from cyclic unsaturated carboxylic acids | Universität Potsdam (DE) | 2013-02-06 | — | — | EP | claimed |
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | claimed |
| EP-1320523-B1 | BRANCHED CHAIN AMINO ACID-DEPENDENT AMINOTRANSFERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | claimed |
| EP-0934276-B1 | ANTHRANILIC ACID DERIVATIVES AS MULTI DRUG RESISTANCE MODULATORS | XENOVA LTD (GB) | 2003-12-17 | — | — | EP | claimed |
| EP-1429768-B1 | NOVEL MEDICAMENTS FOR INHALATION | BOEHRINGER INGELHEIM PHARMA (DE) | 2016-11-16 | — | — | EP | disclosed |
| EP-2554539-B1 | Method for producing gamma-spirolactams from cyclic unsaturated carboxylic acids | UNIVERSITÄT POTSDAM (DE) | 2014-12-10 | — | — | EP | disclosed |
| EP-2554539-A1 | Method for producing gamma-spirolactams from cyclic unsaturated carboxylic acids | Universität Potsdam (DE) | 2013-02-06 | — | — | EP | disclosed |
| EP-1670766-B1 | Bicyclic imino acid derivatives for the treatment of (inter alia) diseases relating to the locomotor system | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-03-21 | — | — | EP | disclosed |
| EP-1763515-B1 | 4-TRIFLUOROMETHOXYPHENOXYBENZOL-4'-SULFONIC ACIDS, METHOD FOR THE PRODUCTION AND USE THEREOF IN MEDICAMENTS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-03-12 | — | — | EP | disclosed |
| EP-1763515-A1 | 4-TRIFLUOROMETHOXYPHENOXYBENZOL-4'-SULFONIC ACIDS, METHOD FOR THE PRODUCTION AND USE THEREOF IN MEDICAMENTS | Sanofi-Aventis Deutschland GmbH (DE) | 2007-03-21 | — | — | EP | disclosed |
| US-6426413-B1 | SUCH AS (N-BENZYLOXYCARBONYL-HYDRAZINO)-ACETIC ACID TERT-BUTYL ESTER; FOR PREVENTING AND TREATING INTERLEUKIN-MEDIATED DISEASES, APOPTOSIS, AUTOIMMUNE DISEASES, BONE DISORDERS, PROLIFERATIVE DISORDERS, INFECTIONS, AND DEGENERATIVE DISEASES | VERTEX PHARMACEUTICALS INCORPORATED | 2002-07-30 | — | — | US | disclosed |
| EP-1062210-A1 | 1,2-DIAZEPANE DERIVATIVES AS INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999046248-A1 | 1,2-DIAZEPANE DERIVATIVES AS INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1999-09-16 | — | — | WO | disclosed |
| EP-0611774-B1 | Production of amides and peptides without racemization in the presence of catalytic amounts of a N-hydroxy-compound | HOFFMANN LA ROCHE (CH) | 1999-05-26 | — | — | EP | disclosed |
| EP-0707006-B1 | Aroyl-piperidine derivatives | NOVARTIS AG (CH) | 1999-04-07 | — | — | EP | disclosed |
| EP-0847994-A1 | Process for the preparation of mixed anhydrides | F. HOFFMANN-LA ROCHE AG (CH) | 1998-06-17 | — | — | EP | disclosed |
| EP-0611774-A1 | Production of amides and peptides without racemization in the presence of catalytic amounts of a N-hydroxy-compound | F. HOFFMANN-LA ROCHE AG (CH) | 1994-08-24 | — | — | EP | disclosed |