Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23930670 | 1.00 | GAA (0.41) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL523536 | 1.00 | GAA (0.41) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL523537 | 1.00 | GAA (0.41) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL20886058 | 1.00 | GAA (0.41) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL19895654 | 1.00 | GAA (0.41) | GAAMGAMSIMGAM2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL19895641 | 0.98 | GAA (0.40) | GAAMGAMSIMGAM2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL23930660 | 0.98 | GAA (0.40) | GAAMGAMSIMGAM2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL23930661 | 0.98 | GAA (0.40) | GAAMGAMSIMGAM2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL19895642 | 0.98 | GAA (0.40) | GAAMGAMSIMGAM2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL30277063 | 0.89 | GAA (0.33) | GAAMGAMSIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203008-A1 | 3-AZABICYCLOALKYL DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | LG CHEM, LTD. (KR) | 2023-06-29 | — | — | US | disclosed |
| US-11634410-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | PFIZER INC. (US) | 2023-04-25 | — | — | US | disclosed |
| EP-4134366-A1 | 3-AZABICYCLOALKYL DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Lg Chem, Ltd. (KR) | 2023-02-15 | — | — | EP | disclosed |
| WO-2021215765-A1 | 3-AZABICYCLOALKYL DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | 주식회사 엘지화학 (KR) | 2021-10-28 | — | — | WO | disclosed |
| US-20210309644-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. (US) | 2021-10-07 | — | — | US | disclosed |
| US-10988463-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | PFIZER INC. (US) | 2021-04-27 | — | — | US | disclosed |
| EP-3397631-B1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER (US) | 2021-04-07 | — | — | EP | disclosed |
| US-20200377482-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. (US) | 2020-12-03 | — | — | US | disclosed |
| US-10787438-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | PFIZER INC. (US) | 2020-09-29 | — | — | US | disclosed |
| US-20200148669-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. (US) | 2020-05-14 | — | — | US | disclosed |
| US-20180037575-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. | 2018-02-08 | — | — | US | disclosed |
| US-20180037575-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. | 2018-02-08 | — | — | US | disclosed |
| US-9809579-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | PFIZER INC. (US) | 2017-11-07 | — | — | US | disclosed |
| US-9809579-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | PFIZER INC. (US) | 2017-11-07 | — | — | US | disclosed |
| WO-2017115205-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. (US) | 2017-07-06 | — | — | WO | disclosed |
| US-20170183328-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. | 2017-06-29 | — | — | US | disclosed |
| US-20170183328-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. | 2017-06-29 | — | — | US | disclosed |
| EP-2417128-B1 | 6-(3-AZA-BICYCLO[3.1.0]HEX-3-YL)-2-PHENYL-PYRIMIDINES AS ADP RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-03-02 | — | — | EP | disclosed |
| US-8288385-B2 | 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-10-16 | — | — | US | disclosed |
| US-20120028989-A1 | 6-(3-AZA-BICYCLO[3.1.0]HEX-3-YL)-2-PHENYL-PYRIMIDINES | VIATRIS ASIA PACIFIC PTE. LTD. (SG) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200148669-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | HK1, GCK, KHK | GAA 288/4885MGAM 92/4885SI 81/4885 |
| US-20210309644-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | HK1, GCK, KHK | GAA 288/4885MGAM 92/4885SI 81/4885 |
| US-20120028989-A1 | 6-(3-AZA-BICYCLO[3.1.0]HEX-3-YL)-2-PHENYL-PYRIMIDINES | P2RY12, P2RY13, P2RY6 | GAA 2681/4885MGAM 4105/4885SI 3372/4885 |
| US-11634410-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | HK1, GCK, KHK | GAA 288/4885MGAM 92/4885SI 81/4885 |
| US-10988463-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | HK1, GCK, KHK | GAA 288/4885MGAM 92/4885SI 81/4885 |
| US-20170183328-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | HK1, GCK, KHK | GAA 288/4885MGAM 92/4885SI 81/4885 |
| US-20230203008-A1 | 3-AZABICYCLOALKYL DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ADCY1, ADCY7 | GAA 2413/4885MGAM 3597/4885SI 2978/4885 |
| US-20200377482-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | HK1, GCK, KHK | GAA 288/4885MGAM 92/4885SI 81/4885 |
| US-20180037575-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | HK1, GCK, KHK | GAA 288/4885MGAM 92/4885SI 81/4885 |
| US-10787438-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | HK1, GCK, KHK | GAA 288/4885MGAM 92/4885SI 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.