Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 19/20 | 0.71 |
| ▸ | THRB | P10828 | 7/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.66 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.52 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL372373 | 0.83 | TGFBR1 (1.00) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL29832035 | 0.83 | TGFBR1 (0.78) | TGFBR1THRBMAPK14TGFBR2MAP3K20 | |
| SCHEMBL373954 | 0.82 | TGFBR1 (0.75) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL409531 | 0.81 | TGFBR1 (0.74) | TGFBR1THRBMAPK14 | |
| SCHEMBL411491 | 0.80 | TGFBR1 (0.80) | TGFBR1THRBMAPK14 | |
| SCHEMBL413691 | 0.80 | TGFBR1 (0.72) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL411832 | 0.80 | TGFBR1 (0.72) | TGFBR1THRBMAPK14 | |
| SCHEMBL29832286 | 0.80 | TGFBR1 (1.00) | TGFBR1THRBMAPK14 | |
| SCHEMBL373535 | 0.80 | TGFBR1 (1.00) | TGFBR1THRBMAPK14 | |
| SCHEMBL411689 | 0.79 | TGFBR1 (0.71) | TGFBR1THRBMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | claimed |