Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.80 |
| ▸ | FBP1 | P09467 | 2/20 | 0.80 |
| ▸ | KDR | P35968 | 2/20 | 0.80 |
| ▸ | AURKA | O14965 | 1/20 | 0.80 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.80 |
| ▸ | INSR | P06213 | 1/20 | 0.80 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.80 |
| ▸ | FLT4 | P35916 | 1/20 | 0.80 |
| ▸ | CLK1 | P49759 | 1/20 | 0.80 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.80 |
| ▸ | TEK | Q02763 | 1/20 | 0.80 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14515609 | 0.92 | EGFR (0.68) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL30505605 | 0.90 | EGFR (1.00) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL2099106 | 0.90 | EGFR (1.00) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL5236221 | 0.89 | KDR (0.78) | EGFRFBP1KDRAURKAERBB2 | |
| Hydrochloric Acid SCHEMBL27887194 | 0.89 | EGFR (0.98) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL22336753 | 0.88 | FBP1 (0.92) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL30520472 | 0.87 | EGFR (0.87) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL13524614 | 0.87 | EGFR (0.87) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL14092460 | 0.86 | EGFR (0.92) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL14863005 | 0.86 | EGFR (0.84) | EGFRFBP1KDRAURKAERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680426-B1 | 1.3.4-TRIAZA-PHENALENE AND 1,3,4,6-TETRAAZAPHENALENE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2007-09-19 | — | — | EP | disclosed |
| US-7217717-B2 | Phenalene derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-05-15 | — | — | US | disclosed |
| EP-1680426-A1 | 1.3.4-TRIAZA-PHENALENE AND 1,3,4,6-TETRAAZAPHENALENE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-19 | — | — | EP | disclosed |
| WO-2004111055-A1 | 1.3.4-TRIAZA-PHENALENE AND 1,3,4,6-TETRAAZAPHENALENE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-12-23 | — | — | WO | disclosed |
| US-20040254205-A1 | Phenalene derivatives | LUK KIN-CHUN (US) | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254205-A1 | Phenalene derivatives | EGFR, ERBB2, ERBB4 | EGFR 1/4885FBP1 2646/4885KDR 504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.