Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.79 |
| ▸ | THRB | P10828 | 2/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.68 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234328 | 0.93 | TGFBR1 (0.69) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL5238145 | 0.92 | TGFBR1 (0.80) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL5240228 | 0.91 | TGFBR1 (0.73) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL5237019 | 0.90 | TGFBR1 (0.73) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL5239564 | 0.90 | TGFBR1 (0.73) | TGFBR1THRBMAPK14 | |
| SCHEMBL413112 | 0.90 | TGFBR1 (0.77) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL413677 | 0.89 | TGFBR1 (0.77) | TGFBR1THRBMAPK14 | |
| SCHEMBL373415 | 0.88 | TGFBR1 (1.00) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL3362621 | 0.88 | TGFBR1 (0.77) | TGFBR1TGFBR2 | |
| SCHEMBL5240569 | 0.88 | TGFBR1 (0.76) | TGFBR1THRBMAPK14TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | claimed |