Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 5/20 | 0.42 |
| ▸ | TYK2 | P29597 | 5/20 | 0.42 |
| ▸ | JAK3 | P52333 | 5/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12832077 | 0.89 | MAP4K4 (0.44) | IKBKBCHUKCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6401995 | 0.86 | JAK2 (0.51) | IKBKBCYP1A2CYP3A4CYP2C9JAK2 | |
| SCHEMBL6068500 | 0.78 | CHEK1 (0.47) | IKBKBCHUKJAK2CHEK1JAK1 | |
| SCHEMBL5463483 | 0.78 | JAK2 (0.65) | IKBKBCHUKCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL29012217 | 0.77 | CHEK1 (0.42) | IKBKBCHUKCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6068379 | 0.77 | JAK2 (0.52) | IKBKBCYP1A2CYP3A4CYP2C9JAK2 | |
| SCHEMBL1496088 | 0.77 | CHEK1 (0.45) | IKBKBCHUKCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8834591 | 0.77 | IKBKB (0.39) | IKBKBCHUKCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL27768306 | 0.77 | IKBKB (0.39) | IKBKBCHUKCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5239521 | 0.76 | IKBKB (0.48) | IKBKBCHUKCYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1950378-A | Thienopyridazines as ikk inhibitors | ROCHE PALO ALTO LLC (CH) | 2007-04-18 | — | — | CN | disclosed |
| EP-1745051-A1 | THIENOPYRIDAZINES AS IKK INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-01-24 | — | — | EP | disclosed |
| US-7135470-B2 | Thienopyridazines as IKK inhibitors | ROCHE PALO ALTO LLC (US) | 2006-11-14 | — | — | US | disclosed |
| US-20050272730-A1 | Thienopyridazines as IKK inhibitors | ROCHE PALO ALTO LLC | 2005-12-08 | — | — | US | disclosed |
| WO-2005105808-A1 | THIENOPYRIDAZINES AS IKK INHIBITORS | F. HOFFMAN-LA ROCHE AG (CH) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272730-A1 | Thienopyridazines as IKK inhibitors | IKBKE, IKBKB, NFKBIA | IKBKB 2/4885CHUK 4/4885CYP1A2 932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.