Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 13/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237417 | 0.93 | AVPR2 (0.41) | AVPR2AVPR1AJAK2TYK2OXTR | |
| SCHEMBL7318351 | 0.85 | AVPR2 (0.42) | AVPR2AVPR1A | |
| SCHEMBL7321300 | 0.78 | TP53 (0.42) | AVPR2AVPR1A | |
| SCHEMBL7320771 | 0.77 | AVPR2 (0.79) | AVPR2AVPR1AOXTR | |
| SCHEMBL5235714 | 0.76 | AVPR2 (0.50) | AVPR2AVPR1AOXTRGPBAR1 | |
| SCHEMBL8561766 | 0.72 | HSD17B3 (0.50) | AVPR2AVPR1A | |
| SCHEMBL7333775 | 0.68 | AVPR2 (0.50) | AVPR2AVPR1AOXTR | |
| SCHEMBL6988374 | 0.68 | AVPR1A (0.58) | AVPR2AVPR1A | |
| SCHEMBL7337401 | 0.67 | MEN1 (0.45) | AVPR2 | |
| SCHEMBL7345789 | 0.67 | AVPR2 (0.50) | AVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804440-B1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-1996022295-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5532235-A | TO TREAT EXCESS RENAL REABSORPTION | AMERICAN CYANAMID COMPANY (US) | 1996-07-02 | — | — | US | disclosed |