Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.56 |
| ▸ | BTK | Q06187 | 5/20 | 0.53 |
| ▸ | SYK | P43405 | 9/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1066489 | 0.92 | BTK (0.60) | AURKABTKSYK | |
| SCHEMBL1068486 | 0.83 | SYK (0.72) | AURKABTKSYK | |
| SCHEMBL1069035 | 0.81 | AURKA (0.50) | AURKASYK | |
| SCHEMBL16716426 | 0.81 | BTK (0.62) | AURKABTKSYK | |
| SCHEMBL12962408 | 0.81 | BTK (0.60) | AURKABTKSYK | |
| SCHEMBL1068125 | 0.80 | BTK (0.62) | AURKABTKSYK | |
| SCHEMBL12962452 | 0.80 | BTK (0.50) | AURKABTKSYK | |
| SCHEMBL1066572 | 0.80 | BTK (0.61) | AURKABTKSYK | |
| SCHEMBL12637975 | 0.79 | BTK (0.60) | AURKABTKSYK | |
| SCHEMBL1066039 | 0.79 | BTK (0.60) | AURKABTKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812442-A2 | IMIDAZO[1,2-A]PYRAZIN-8-YLAMINES USEFUL AS MODULATORS OF KINASE ACTIVITY | CGI Pharmaceuticals, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006053121-A2 | IMIDAZO[1 , 2-A] PYRAZIN-8-YLAMINES USEFUL AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | disclosed |