Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 18/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL745736 | 1.00 | CCR2 (0.63) | CCR2KCNH2SLC6A5 | |
| SCHEMBL742586 | 0.87 | CCR2 (0.59) | CCR2KCNH2SLC6A5 | |
| SCHEMBL742585 | 0.87 | CCR2 (0.59) | CCR2KCNH2SLC6A5 | |
| SCHEMBL5235112 | 0.87 | CCR2 (0.59) | CCR2KCNH2SLC6A5 | |
| SCHEMBL742587 | 0.87 | CCR2 (0.59) | CCR2KCNH2SLC6A5 | |
| SCHEMBL765654 | 0.81 | CCR2 (0.56) | CCR2 | |
| SCHEMBL12208931 | 0.81 | CCR2 (0.56) | CCR2 | |
| SCHEMBL744533 | 0.81 | CCR2 (0.70) | CCR2KCNH2 | |
| SCHEMBL13049211 | 0.81 | CCR2 (0.70) | CCR2KCNH2 | |
| SCHEMBL13049208 | 0.80 | CCR2 (0.57) | CCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565436-A4 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORP (US) | 2007-07-18 | — | — | EP | disclosed |
| EP-1565436-A2 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORPORATION (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004050024-A2 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORPORATION (US) | 2004-06-17 | — | — | WO | disclosed |