Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 17/20 | 0.47 |
| ▸ | HTR1D | P28221 | 17/20 | 0.47 |
| ▸ | HTR1B | P28222 | 17/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR1E | P28566 | 1/20 | 0.45 |
| ▸ | HTR1F | P30939 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HTR5A | P47898 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214741 | 0.73 | HTR1D (0.60) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL5210689 | 0.73 | HTR1A (0.83) | HTR1AHTR1DHTR1BSLC6A4ADRB2 | |
| SCHEMBL6834120 | 0.70 | HTR1D (0.62) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL5251503 | 0.68 | HTR1D (0.59) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL5213797 | 0.68 | HTR1A (0.79) | HTR1AHTR1DHTR1BSLC6A4ADRB2 | |
| SCHEMBL5211540 | 0.67 | HTR1A (0.78) | HTR1AHTR1DHTR1BSLC6A4ADRB2 | |
| SCHEMBL6826132 | 0.67 | HTR1A (0.59) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL5213749 | 0.67 | HTR1D (0.49) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL5205795 | 0.66 | HTR1A (0.81) | HTR1AHTR1DHTR1BSLC6A4ADRB2 | |
| SCHEMBL5220146 | 0.65 | HTR1D (0.50) | HTR1AHTR1DHTR1BSLC6A4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480972-B1 | COMPOUNDS POSSESSING AFFINITY AT 5HT1-TYPE RECEPTORS AND USE THEREOF IN THERAPY OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2007-04-11 | — | — | EP | claimed |