Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 5/20 | 0.55 |
| ▸ | HTR6 | P50406 | 8/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.42 |
| ▸ | PFKFB4 | Q16877 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13508281 | 0.79 | NPSR1 (0.59) | HTR6NPSR1L3MBTL1CMA1PFKFB3 | |
| SCHEMBL5242244 | 0.77 | SLC6A9 (0.63) | SLC6A9L3MBTL1 | |
| SCHEMBL6629302 | 0.77 | SLC6A9 (0.63) | SLC6A9L3MBTL1 | |
| SCHEMBL5240631 | 0.73 | SLC6A9 (0.73) | SLC6A9 | |
| SCHEMBL5243324 | 0.73 | SLC6A9 (0.73) | SLC6A9 | |
| SCHEMBL5243328 | 0.73 | SLC6A9 (0.73) | SLC6A9 | |
| SCHEMBL5243999 | 0.72 | SLC6A9 (0.64) | SLC6A9L3MBTL1 | |
| SCHEMBL3686019 | 0.71 | NPSR1 (0.58) | HTR6NPSR1L3MBTL1CMA1DRD2 | |
| SCHEMBL8367106 | 0.71 | SLC6A9 (1.00) | SLC6A9 | |
| SCHEMBL5286043 | 0.71 | SLC6A9 (1.00) | SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1455777-B1 | GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2007-11-21 | — | — | EP | claimed |
| EP-1455777-B1 | GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2007-11-21 | — | — | EP | disclosed |
| WO-2003055478-A1 | GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-07-10 | — | — | WO | disclosed |