Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 8/20 | 0.53 |
| ▸ | DRD2 | P14416 | 10/20 | 0.53 |
| ▸ | DRD4 | P21917 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5276539 | 1.00 | DRD3 (0.53) | DRD3DRD2DRD4MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9787102 | 0.87 | DRD3 (0.61) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL5241589 | 0.84 | DRD3 (0.47) | DRD3DRD2HTR7HTR1DHTR1B | |
| SCHEMBL5239898 | 0.84 | DRD3 (0.48) | DRD3DRD2DRD4CYP2D6LMNA | |
| SCHEMBL5237088 | 0.84 | DRD2 (0.43) | DRD3DRD2HTR7HTR1DHTR1B | |
| SCHEMBL5240158 | 0.84 | DRD3 (0.48) | DRD3DRD2DRD4CYP2D6LMNA | |
| SCHEMBL5238243 | 0.81 | DRD2 (0.46) | DRD3DRD2DRD4CYP2D6LMNA | |
| SCHEMBL5238250 | 0.81 | DRD2 (0.46) | DRD3DRD2DRD4CYP2D6LMNA | |
| SCHEMBL5238113 | 0.79 | DRD3 (0.51) | DRD3DRD2HTR7 | |
| SCHEMBL4107728 | 0.79 | DRD2 (0.43) | DRD3DRD2HTR7HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819690-A2 | CHROMAN COMPOUNDS | Pfizer Limited (GB) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006056850-A2 | CHROMAN COMPOUNDS | PFIZER LIMITED (GB) | 2006-06-01 | — | — | WO | disclosed |