Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.47 |
| ▸ | HTR1B | P28222 | 2/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.36 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5242925 | 0.99 | HTR6 (0.46) | HTR6HTR1BHTR1DSLC6A4HRH1 | |
| SCHEMBL5241679 | 0.86 | HTR6 (0.50) | HTR6HTR1BSLC6A4KDM4EHTR2A | |
| SCHEMBL5241872 | 0.85 | HTR6 (0.54) | HTR6HTR1BHTR1DSLC6A4HRH1 | |
| Hydrochloric Acid SCHEMBL5243564 | 0.85 | HTR6 (0.49) | HTR6HTR1BSLC6A4KDM4EHTR2A | |
| SCHEMBL5240623 | 0.85 | HTR6 (0.47) | HTR6HTR1BHTR1DKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5243162 | 0.84 | HTR6 (0.53) | HTR6HTR1BHTR1DSLC6A4HRH1 | |
| SCHEMBL5240551 | 0.80 | HTR6 (0.72) | HTR6KDM4EALDH1A1TDP1KMT2A | |
| SCHEMBL5241030 | 0.80 | HTR6 (0.44) | HTR6HTR2ARAB9AMETGPR84 | |
| Hydrochloric Acid SCHEMBL5244077 | 0.79 | HTR6 (0.71) | HTR6KDM4EALDH1A1TDP1KMT2A | |
| SCHEMBL5242280 | 0.78 | HTR6 (0.41) | HTR6KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569638-B1 | AMINOALKOXYINDOLES AS 5-HT6-RECEPTOR LIGANDS FOR THE TREATMENT OF CNS-DISORDERS | HOFFMANN LA ROCHE (CH) | 2007-09-05 | — | — | EP | claimed |
| EP-1569638-B1 | AMINOALKOXYINDOLES AS 5-HT6-RECEPTOR LIGANDS FOR THE TREATMENT OF CNS-DISORDERS | HOFFMANN LA ROCHE (CH) | 2007-09-05 | — | — | EP | disclosed |