SCHEMBL524230

SCHEMBL524230

Nc1[nH]c(=O)nc2[nH]c(=O)[nH]c12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.53
ADORA3 P0DMS8 1/20 0.40
ADORA2A P29274 1/20 0.40
ADORA1 P30542 1/20 0.40
RPS6KA3 P51812 2/20 0.37
CHEK1 O14757 1/20 0.35
AURKA O14965 1/20 0.35
DAPK3 O43293 1/20 0.35
JAK2 O60674 1/20 0.35
ABL1 P00519 1/20 0.35
NTRK1 P04629 1/20 0.35
CSF1R P07333 1/20 0.35
RET P07949 1/20 0.35
IGF1R P08069 1/20 0.35
PDGFRB P09619 1/20 0.35
PIM1 P11309 1/20 0.35
FGFR1 P11362 1/20 0.35
PRKACA P17612 1/20 0.35
KDR P35968 1/20 0.35
MAP2K2 P36507 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Uric Acid SCHEMBL29364704 0.72 MAPT (0.42) MAPTADORA3ADORA2AADORA1XDH
SCHEMBL22144 0.70 MAPT (1.00) MAPTRPS6KA3DYRK1AXDHADORA2B
SCHEMBL1511914 0.68 MAPT (0.52) MAPTADORA3ADORA2AADORA1RPS6KA3
SCHEMBL21895408 0.67 MAPT (0.50) MAPTADORA3ADORA2AADORA1RPS6KA3
SCHEMBL21895487 0.67 MAPT (0.50) MAPTADORA3ADORA2AADORA1RPS6KA3
SCHEMBL14933942 0.65 MAPT (0.48) MAPTADORA3ADORA2AADORA1RPS6KA3
SCHEMBL447389 0.65 MAPT (0.84) MAPTRPS6KA3DYRK1AXDHADORA2B
SCHEMBL15713240 0.65 GDA (0.44) MAPTLMNAL3MBTL1GDAPNP
SCHEMBL36691 0.64
SCHEMBL31495235 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 228 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4681774-A2 KHK INHIBITORS Gilead Sciences, Inc. (US) 2026-01-21 EP claimed
EP-4313967-B1 KHK INHIBITORS GILEAD SCIENCES INC (US) 2025-11-12 EP claimed
EP-4313967-A1 KHK INHIBITORS GILEAD SCIENCES, INC. (US) 2024-02-07 EP claimed
US-20230416361-A1 ENGINEERED CD200R ANTIBODIES AND USES THEREOF OXFORD UNIVERSITY INNOVATION LIMITED (GB) 2023-12-28 US claimed
CN-117120429-A KHK inhibitor 吉利德科学公司 2023-11-24 CN claimed
WO-2023196866-A1 ENGINEERED CD200R ANTIBODIES AND USES THEREOF MIROBIO LIMITED (GB) 2023-10-12 WO claimed
US-20230079863-A1 KHK INHIBITORS GILEAD SCIENCES, INC. 2023-03-16 US claimed
WO-2022212194-A1 KHK INHIBITORS GILEAD SCIENCES, INC. (US) 2022-10-06 WO claimed
EP-3519558-A1 USE OF ENGINEERED RENAL TISSUES IN ASSAYS Organovo, Inc. (US) 2019-08-07 EP claimed
WO-2018064323-A1 USE OF ENGINEERED RENAL TISSUES IN ASSAYS ORGANOVO, INC. (US) 2018-04-05 WO claimed
WO-2009127230-A1 MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION CUREVAC GMBH (DE) 2009-10-22 WO claimed
JP-3065650-A None JP disclosed
US-20260092053-A1 KHK INHIBITORS GILEAD SCIENCES INC (US) 2026-04-02 US disclosed
EP-4705318-A2 KIDNEY-TARGETING AAV CAPSIDS AND METHODS OF USE THEREOF Oregon Health & Science University (US) 2026-03-11 EP disclosed
US-20260042788-A1 STAT6 COMPOUNDS GILEAD SCIENCES INC (US) 2026-02-12 US disclosed
EP-0504279-A4 FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES 1993-02-17 EP disclosed
EP-0504279-A1 FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES. CHEMGEN CORP (US) 1992-09-23 EP disclosed
WO-1991009130-A1 FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES CHEMGEN CORPORATION (US) 1991-06-27 WO disclosed
JP-H0365650-A METHOD OF MEASURING DIHYDROXYADENINE FUJIREBIO INC 1991-03-20 JP disclosed
JP-H00365650-A 0001-01-01 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260042788-A1 STAT6 COMPOUNDS STAT6, IL6ST, NFATC1 MAPT 4410/4885ADORA3 2810/4885ADORA2A 3060/4885
US-20260092053-A1 KHK INHIBITORS KHK, SLC5A2, HK1 MAPT 1585/4885ADORA3 3619/4885ADORA2A 3124/4885
US-20230079863-A1 KHK INHIBITORS KHK, KHDRBS1, NADK MAPT 3104/4885ADORA3 4579/4885ADORA2A 4220/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.