SCHEMBL447389

SCHEMBL447389

Nc1nc2[nH]c(=O)[nH]c(=O)c2[nH]1

nearest known ligand 0.84

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.84
PNP P00491 2/20 0.54
ADORA2B P29275 1/20 0.49
RPS6KA3 P51812 1/20 0.46
GDA Q9Y2T3 2/20 0.44
ACHE P22303 1/20 0.44
ALDH1A1 P00352 3/20 0.42
HSD17B10 Q99714 3/20 0.42
HPGD P15428 2/20 0.42
ALOX15 P16050 2/20 0.42
CYP3A4 P08684 1/20 0.42
MAPK1 P28482 1/20 0.42
DYRK1A Q13627 1/20 0.40
KDM4E B2RXH2 2/20 0.39
THRB P10828 2/20 0.39
LMNA P02545 1/20 0.39
GLA P06280 1/20 0.39
PMP22 Q01453 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7296117 0.98 MAPT (0.81) MAPTPNPADORA2BRPS6KA3GDA
SCHEMBL22144 0.91 MAPT (1.00) MAPTPNPADORA2BRPS6KA3GDA
SCHEMBL5479007 0.81 MAPT (0.62) MAPTPNPALDH1A1HSD17B10HPGD
Leucopterin SCHEMBL14080077 0.80 MAPT (0.73) MAPTPNPALDH1A1HSD17B10HPGD
SCHEMBL5479015 0.79 MAPT (0.60) MAPTPNPADORA2BRPS6KA3ALDH1A1
SCHEMBL3513712 0.78 MAPT (0.75) MAPTPNPADORA2BRPS6KA3GDA
SCHEMBL159446 0.77 MAPT (0.68) MAPTPNPALDH1A1HSD17B10HPGD
Triphosphate SCHEMBL6461190 0.75 MAPT (0.68) MAPTPNPADORA2BDYRK1AXDH
SCHEMBL1682869 0.75 MAPT (0.68) MAPTPNPADORA2BRPS6KA3ALDH1A1
SCHEMBL2206471 0.75 MAPT (0.66) MAPTPNPALDH1A1HSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 615 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119817601-A Composite microbial agent and application thereof in improving saline-alkali stress resistance of crops 山东农大肥业科技股份有限公司 2025-04-15 CN claimed
US-20230285556-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER OMEROS CORPORATION 2023-09-14 US claimed
WO-2023039578-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER OMEROS CORPORATION (US) 2023-03-16 WO claimed
EP-3900712-A1 GPCR HETEROMER INHIBITORS AND USES THEREOF GPCR Therapeutics, Inc. (KR) 2021-10-27 EP claimed
EP-3727371-A1 GPCR HETEROMER INHIBITORS AND USES THEREOF GPCR Therapeutics, Inc. (KR) 2020-10-28 EP claimed
US-20190209594-A1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CHEMORESISTANT ACUTE MYELOID LEUKEMIA (AML) UNIVERSITE PAUL SABATIER TOULOUSE III (FR) 2019-07-11 US claimed
EP-3452092-A1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CHEMORESISTANT ACUTE MYELOID LEUKEMIA (AML) INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2019-03-13 EP claimed
WO-2017191300-A1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CHEMORESISTANT ACUTE MYELOID LEUKEMIA (AML) INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2017-11-09 WO claimed
EP-2507241-A1 METHANOCARBA ADENOSINE DERIVATIVES AND DENDRIMER CONJUGATES THEREOF The U.S.A. As Represented By The Secretary, Department Of Health And Human Services (US) 2012-10-10 EP claimed
US-20110189255-A1 DRUG-ELUTING STENTS FOR ADENOSINE RECEPTOR MODULATION PURDUE RESEARCH FOUNDATION 2011-08-04 US claimed
WO-1994024133-A1 RING-SUBSTITUTED CELL SIGNALING INHIBITORS CELL THERAPEUTICS, INC. (US) 1994-10-27 WO claimed
WO-1994022863-A1 SECOND MESSENGER CELL SIGNALING INHIBITORS CELL THERAPEUTICS, INC. (US) 1994-10-13 WO claimed
WO-1994016704-A1 OXIME-SUBSTITUTED THERAPEUTIC COMPOUNDS CELL THERAPEUTICS, INC. (US) 1994-08-04 WO claimed
WO-1994015605-A1 ACETAL OR KETAL SUBSTITUTED THERAPEUTIC COMPOUNDS CELL THERAPEUTICS, INC. (US) 1994-07-21 WO claimed
WO-1994011370-A1 SUBSTITUTED AMINO ALKYL COMPOUNDS CELL THERAPEUTICS, INC. (US) 1994-05-26 WO claimed
WO-1994011001-A1 HYDROXYL-CONTAINING COMPOUNDS CELL THERAPEUTICS, INC. (US) 1994-05-26 WO claimed
CN-1047502-A The preparation method of 8-substituted xanthine BEECHAM WUELFING GMBH & CO KG (DE) 1990-12-05 CN claimed
EP-0260127-A2 Xanthine derivatives, their preparation and pharmaceutical compositions containing them BEECHAM - WUELFING GmbH & Co. KG (DE) 1988-03-16 EP claimed
EP-0107165-B1 SUBSTITUTED 9H-8-OXO-PYRIMIDO(2,1-F)PURINE-2,4-DIONES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SCHERING CORPORATION (US) 1987-04-15 EP claimed
EP-0107165-A1 Substituted 9H-8-oxo-pyrimido(2,1-f)purine-2,4-diones, process for their production and pharmaceutical compositions containing them SCHERING CORPORATION (US) 1984-05-02 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230285556-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER TP53, CD4, MCL1 MAPT 3945/4885PNP 2571/4885ADORA2B 2902/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.