Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 5/20 | 0.38 |
| ▸ | HTR2C | P28335 | 5/20 | 0.38 |
| ▸ | HTR2B | P41595 | 5/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | FADS1 | O60427 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30639134 | 0.76 | KDM4E (0.48) | CYP19A1KDM4EGFERL3MBTL1HTR2A | |
| SCHEMBL27729368 | 0.74 | GFER (0.43) | CYP19A1KDM4EGFERHTR2AHTR2C | |
| SCHEMBL26220380 | 0.74 | KDM4E (0.47) | CYP19A1KDM4EGFERL3MBTL1HTR2A | |
| SCHEMBL1138365 | 0.74 | KDM4E (0.47) | CYP19A1KDM4EGFERL3MBTL1HTR2A | |
| SCHEMBL21452381 | 0.71 | CYP19A1 (0.42) | CYP19A1KDM4EL3MBTL1HTR2AHTR2C | |
| SCHEMBL16936925 | 0.69 | KDM4E (0.48) | CYP19A1KDM4EGFERHTR2AHTR2C | |
| SCHEMBL11622159 | 0.67 | KDM4E (0.42) | CYP19A1KDM4EL3MBTL1PKMALDH1A1 | |
| SCHEMBL27219487 | 0.67 | HTR7 (0.35) | CYP19A1HTR7 | |
| SCHEMBL6781180 | 0.66 | CYP19A1 (0.46) | CYP19A1KDM4EGFERL3MBTL1HTR2A | |
| SCHEMBL730107 | 0.65 | ESR2 (0.47) | CYP19A1KDM4EGFERHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863479-A1 | TETRAHYDROTHIOPYRANO PYRAZOLE CANNABINOID MODULATORS CROSS REFERENCE TO RELATED APPLICATIONS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006107561-A1 | TETRAHYDROTHIOPYRANO PYRAZOLE CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-10-12 | — | — | WO | disclosed |