Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5183561 | 0.89 | LMNA (0.52) | HTR7TP53BP1L3MBTL3L3MBTL1LMNA | |
| SCHEMBL5241842 | 0.86 | LMNA (0.43) | LMNAMAPTSUV39H2CCR1MEN1 | |
| SCHEMBL5244297 | 0.86 | F10 (0.41) | HTR1AHTR7LMNAMAPTCCR1 | |
| SCHEMBL5242970 | 0.85 | LMNA (0.43) | HTR1AHTR7LMNAMAPTCCR1 | |
| SCHEMBL5242204 | 0.85 | LMNA (0.42) | LMNAMAPTSUV39H2CCR1MEN1 | |
| SCHEMBL5245094 | 0.83 | SUV39H2 (0.44) | LMNAMAPTSUV39H2 | |
| SCHEMBL5244935 | 0.83 | LMNA (0.41) | HTR1AHTR7LMNAMAPTCCR1 | |
| SCHEMBL5242275 | 0.82 | LMNA (0.40) | HTR1AHTR7LMNAMAPTCCR1 | |
| SCHEMBL5240767 | 0.82 | SUV39H2 (0.42) | LMNAMAPTSUV39H2CCR1 | |
| SCHEMBL5242277 | 0.81 | BRD4 (0.40) | HTR1AHTR7LMNAMAPTCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756107-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2006009789-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2006-01-26 | — | — | WO | claimed |