Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4212318 | 0.88 | LMNA (0.71) | KMT2AMEN1TDP1LMNAMCOLN3 | |
| SCHEMBL7050029 | 0.86 | KMT2A (0.69) | KMT2AMEN1TDP1LMNAMCOLN3 | |
| SCHEMBL15503757 | 0.80 | MEN1 (1.00) | KMT2AMEN1TDP1LMNAMCOLN3 | |
| SCHEMBL15154851 | 0.79 | KMT2A (0.83) | KMT2AMEN1TDP1LMNAMCOLN3 | |
| SCHEMBL28352182 | 0.79 | HTT (0.77) | KMT2AMEN1TDP1LMNAALDH1A1 | |
| SCHEMBL266466 | 0.79 | MEN1 (0.77) | KMT2AMEN1TDP1LMNAMCOLN3 | |
| SCHEMBL15014573 | 0.79 | MEN1 (0.77) | KMT2AMEN1TDP1LMNAMCOLN3 | |
| SCHEMBL266385 | 0.78 | LMNA (1.00) | KMT2AMEN1TDP1LMNAMCOLN3 | |
| SCHEMBL266490 | 0.78 | MEN1 (0.75) | KMT2AMEN1TDP1LMNAMCOLN3 | |
| SCHEMBL2839822 | 0.78 | MEN1 (0.75) | KMT2AMEN1TDP1LMNAMCOLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819669-A2 | NOVEL INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | Kalypsys, Inc. (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006063294-A2 | NOVEL INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2006-06-15 | — | — | WO | disclosed |