Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.47 |
| ▸ | HTR1B | P28222 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1F | P30939 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243831 | 0.83 | HTR6 (0.56) | HTR6HTR1BMEN1ALDH1A1LMNA | |
| SCHEMBL5242040 | 0.83 | HTR6 (0.68) | HTR6HTR1BBCHEHTR1D | |
| Hydrochloric Acid SCHEMBL5652927 | 0.82 | HTR6 (0.55) | HTR6HTR1BMEN1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL5243171 | 0.82 | HTR6 (0.67) | HTR6HTR1BBCHEHTR1D | |
| SCHEMBL5243243 | 0.81 | TDP1 (0.46) | HTR6TSHRCYP2C19HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL5243005 | 0.80 | TDP1 (0.45) | HTR6TSHRCYP2C19HTR1AHTR7 | |
| SCHEMBL5243945 | 0.80 | HTR6 (0.71) | HTR6HTR1BBCHEHTR1AHTR1D | |
| SCHEMBL931908 | 0.79 | HTR6 (0.62) | HTR6MEN1ALDH1A1LMNAHPGD | |
| SCHEMBL20742938 | 0.75 | HTR6 (0.60) | HTR6HTR1BMEN1ALDH1A1LMNA | |
| SCHEMBL30184484 | 0.75 | HTR6 (0.60) | HTR6HTR1BMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569638-B1 | AMINOALKOXYINDOLES AS 5-HT6-RECEPTOR LIGANDS FOR THE TREATMENT OF CNS-DISORDERS | HOFFMANN LA ROCHE (CH) | 2007-09-05 | — | — | EP | claimed |