SCHEMBL524434

SCHEMBL524434

O=c1ccccc(O)c1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DBH P09172 3/20 1.00
MMP2 P08253 2/20 0.65
TDP1 Q9NUW8 3/20 0.53
ALDH1A1 P00352 3/20 0.53
HPGD P15428 3/20 0.53
ALOX15 P16050 3/20 0.53
RECQL P46063 3/20 0.53
HSD17B10 Q99714 3/20 0.53
EGFR P00533 2/20 0.53
CA2 P00918 2/20 0.53
LMNA P02545 2/20 0.53
FYN P06241 2/20 0.53
MMP9 P14780 2/20 0.53
CDK2 P24941 2/20 0.53
ADAMTS4 O75173 1/20 0.53
CA1 P00915 1/20 0.53
MMP8 P22894 1/20 0.53
CA6 P23280 1/20 0.53
MMP12 P39900 1/20 0.53
ADAMTS5 Q9UNA0 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL524707 0.86 DBH (1.00) DBHMMP2TDP1ALDH1A1HPGD
Tropolone SCHEMBL42739 0.79
Tropolone SCHEMBL9643338 0.77 DBH (0.94) DBHMMP2TDP1ALDH1A1HPGD
Tropolone SCHEMBL5969452 0.77 DBH (0.94) DBHMMP2TDP1ALDH1A1HPGD
Tropolone SCHEMBL29029471 0.77 DBH (0.94) DBHMMP2TDP1ALDH1A1HPGD
Tropolone SCHEMBL9643396 0.77 DBH (0.94) DBHMMP2TDP1ALDH1A1HPGD
Tropolone SCHEMBL531387 0.77 DBH (0.94) DBHMMP2TDP1ALDH1A1HPGD
Tropolone SCHEMBL9644163 0.77 DBH (0.94) DBHMMP2TDP1ALDH1A1HPGD
Tropolone SCHEMBL16910519 0.77 DBH (0.94) DBHMMP2TDP1ALDH1A1HPGD
Tropolone SCHEMBL9644286 0.77 DBH (0.94) DBHMMP2TDP1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4021413-A1 LIPOSOMAL TROPONOID COMPOUND FORMULATIONS United States Government as Represented by The Department of Veterans Affairs (US) 2022-07-06 EP claimed
WO-2021041776-A1 LIPOSOMAL TROPONOID COMPOUND FORMULATIONS UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) 2021-03-04 WO claimed
WO-2019118803-A1 CHEMICAL ENTITIES FOR LYTIC ACTIVATION OF KSHV AND THERAPEUTIC TARGETING OF VIRAL ENZYMES/PROTEINS THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2019-06-20 WO claimed
EP-1976497-A2 TREATMENT OF VIRAL INFECTIONS THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2008-10-08 EP claimed
WO-2007065007-A9 TREATMENT OF VIRAL INFECTIONS US HEALTH (US) 2007-09-13 WO claimed
WO-2007065007-A2 TREATMENT OF VIRAL INFECTIONS GOVERNMENT OF THE U.S.A., AS REPERSENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2007-06-07 WO claimed
WO-2019195181-A9 ANTIBODIES AND FRAGMENTS THEREOF THAT BIND HEPATITIS B VIRUS PROTEIN X GILEAD SCIENCES, INC. (US) 2023-07-06 WO disclosed
US-11421223-B2 Processes and host cells for genome, pathway, and biomolecular engineering ENEVOLV, INC. (US) 2022-08-23 US disclosed
EP-4021413-A1 LIPOSOMAL TROPONOID COMPOUND FORMULATIONS United States Government as Represented by The Department of Veterans Affairs (US) 2022-07-06 EP disclosed
WO-2022087422-A9 PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AND RELATED USES CHULALONGKORN UNIVERSITY (TH) 2022-06-09 WO disclosed
WO-2022087422-A1 PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AND RELATED USES CHULALONGKORN UNIVERSITY (TH) 2022-04-28 WO disclosed
EP-3935065-A1 3'3'-CYCLIC DINUCLEOTIDE ANALOGUE COMPRISING A CYCLOPENTANYL MODIFIED NUCLEOTIDE AS STING MODULATOR Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. (CZ) 2022-01-12 EP disclosed
EP-3873608-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS HAVING HPK1 INHIBITORY ACTIVITY GILEAD SCIENCES, INC. (US) 2021-09-08 EP disclosed
WO-2012013967-A2 NEW USES SYNTOPIX GROUP PLC (GB) 2012-02-02 WO disclosed
EP-1976497-A2 TREATMENT OF VIRAL INFECTIONS THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2008-10-08 EP disclosed
CN-101044403-A Methods for altering surface characteristics of microspheres LUMINEX CORP (US) 2007-09-26 CN disclosed
WO-2007065007-A9 TREATMENT OF VIRAL INFECTIONS US HEALTH (US) 2007-09-13 WO disclosed
WO-2007065007-A2 TREATMENT OF VIRAL INFECTIONS GOVERNMENT OF THE U.S.A., AS REPERSENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2007-06-07 WO disclosed
US-4883758-A Biologically pure culture of the microorganism Streptomycas tropolofaciens used for producing 3,7-dihydroxytropolone and antitumor use BRISTOL-MYERS COMPANY (US) 1989-11-28 US disclosed
US-4833079-A CULTURE OF STREPTOMYCES BRISTOL-MYERS COMPANY (US) 1989-05-23 US disclosed