Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.70 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.70 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.70 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.70 |
| ▸ | HTR1A | P08908 | 2/20 | 0.66 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.66 |
| ▸ | HTR2A | P28223 | 2/20 | 0.66 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.66 |
| ▸ | HTR2B | P41595 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2936071 | 1.00 | REN (1.00) | RENADRA1AKCNH2CYP3A4ADRA2A | |
| SCHEMBL2931213 | 0.90 | REN (0.81) | RENADRA1AKCNH2CYP3A4ADRA2A | |
| SCHEMBL2931215 | 0.90 | REN (0.81) | RENADRA1AKCNH2CYP3A4ADRA2A | |
| SCHEMBL8263522 | 0.89 | REN (0.82) | RENADRA1AKCNH2CYP3A4ADRA2A | |
| SCHEMBL2929255 | 0.88 | REN (1.00) | RENADRA1AKCNH2CYP3A4ADRA2A | |
| SCHEMBL2936912 | 0.88 | REN (1.00) | RENADRA1AKCNH2CYP3A4ADRA2A | |
| SCHEMBL2929257 | 0.88 | REN (1.00) | RENADRA1AKCNH2CYP3A4ADRA2A | |
| SCHEMBL13404586 | 0.88 | REN (1.00) | RENADRA1AKCNH2CYP3A4ADRA2A | |
| SCHEMBL2937108 | 0.87 | REN (1.00) | RENADRA1AKCNH2CYP3A4ADRA2A | |
| SCHEMBL5325423 | 0.87 | REN (1.00) | RENADRA1AKCNH2CYP3A4ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836163-A2 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | Novartis AG (CH) | 2007-09-26 | — | — | EP | claimed |
| WO-2006066896-A2 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2006-06-29 | — | — | WO | claimed |