Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 17/20 | 0.61 |
| ▸ | CDC7 | O00311 | 3/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | ROS1 | P08922 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243274 | 0.79 | LIMK1 (0.52) | LIMK1CDC7CDK5PLK4AURKA | |
| SCHEMBL5245414 | 0.77 | PIM1 (0.48) | CDC7CDK5AURKADAPK3DYRK3 | |
| SCHEMBL12822244 | 0.76 | LIMK1 (1.00) | LIMK1CDC7CDK5PLK4AURKA | |
| SCHEMBL12970350 | 0.72 | LIMK1 (0.76) | LIMK1CDC7CDK5PLK4AURKA | |
| SCHEMBL12969821 | 0.72 | LIMK1 (0.76) | LIMK1CDK5MAP4K4KDRCDK5R1 | |
| SCHEMBL12969829 | 0.69 | LIMK1 (0.72) | LIMK1CDC7CDK5PLK4AURKA | |
| SCHEMBL12969576 | 0.69 | LIMK1 (1.00) | LIMK1CDC7CDK5IKBKBCDK5R1 | |
| SCHEMBL12969575 | 0.67 | LIMK1 (0.71) | LIMK1CDK5CDK5R1LIMK2CLK1 | |
| SCHEMBL12969542 | 0.67 | LIMK1 (0.71) | LIMK1CDK5MKNK2CDK5R1LIMK2 | |
| SCHEMBL4899938 | 0.65 | LIMK1 (0.66) | LIMK1CDC7CDK5PLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819710-A1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | Laboratorios Almirall, S.A. (ES) | 2007-08-22 | — | — | EP | claimed |
| WO-2006058724-A1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | LABORATORIOS ALMIRALL, S.A. (ES) | 2006-06-08 | — | — | WO | claimed |
| EP-1819710-A1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | Laboratorios Almirall, S.A. (ES) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006058724-A1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | LABORATORIOS ALMIRALL, S.A. (ES) | 2006-06-08 | — | — | WO | disclosed |