Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5244407 | 0.93 | CNR2 (0.33) | NOTUMBRAFCNR2PSEN1PSEN2 | |
| SCHEMBL5246807 | 0.91 | BRD4 (0.38) | POLBMAPT | |
| SCHEMBL5247054 | 0.90 | NOTUM (0.34) | NOTUMBRAFDGAT1PSEN1PSEN2 | |
| SCHEMBL3116642 | 0.89 | TP53 (0.40) | BRAFLRRK2 | |
| SCHEMBL3111906 | 0.89 | SMPD1 (0.38) | NOTUMDGAT1 | |
| SCHEMBL3117550 | 0.89 | NOTUM (0.39) | NOTUMBRAFDGAT1PSEN1PSEN2 | |
| SCHEMBL5247629 | 0.89 | DGAT1 (0.34) | NOTUMDGAT1 | |
| SCHEMBL5249178 | 0.89 | SMPD1 (0.34) | NOTUMDGAT1 | |
| SCHEMBL5244565 | 0.88 | NOTUM (0.35) | NOTUMBRAFCNR2POLBMAPT | |
| SCHEMBL5244319 | 0.88 | MEN1 (0.36) | DGAT1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1867331-A1 | TRIAZOLE DERIVATIVE AND THE USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2007-12-19 | — | — | EP | disclosed |