Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | TOP2A | P11388 | 2/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | LSS | P48449 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5245050 | 0.93 | ADRB2 (0.34) | HRH3MAOBHRH1BCHEMAOA | |
| SCHEMBL5246318 | 0.91 | MAPK1 (0.37) | HRH3HRH1CXCR1MAOAACHE | |
| SCHEMBL5244959 | 0.90 | FLT3 (0.34) | HRH3HRH1 | |
| SCHEMBL5244926 | 0.84 | MAPK1 (0.38) | HRH3HRH1CXCR1MAOAACHE | |
| SCHEMBL5244955 | 0.83 | HTR2C (0.33) | HRH1 | |
| SCHEMBL5245045 | 0.83 | NPY5R (0.45) | HRH3HTR1BHRH1MAOAACHE | |
| SCHEMBL4035884 | 0.78 | CACNA1H (0.36) | HRH3CACNA1HCACNA1BHTR1BMAOB | |
| Hydrochloric Acid SCHEMBL4038349 | 0.77 | CACNA1H (0.35) | HRH3CACNA1HCACNA1BMAOBLSS | |
| SCHEMBL5244856 | 0.76 | NPY5R (0.36) | HRH3HRH1MAOAACHE | |
| SCHEMBL5182469 | 0.76 | NR4A2 (0.35) | HRH3CACNA1HCACNA1BHTR1BMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684751-B1 | USE OF 1-THIA-DIBENZO E,H AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS | GLAXOSMITHKLINE ZAGREB (HR) | 2007-09-12 | — | — | EP | claimed |
| US-20070078123-A1 | 1-Thia-3-aza-dibenzo[e,h]azulenes for the treatment of central nervous system diseases and disorders | PILVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2007-04-05 | — | — | US | claimed |
| EP-1684751-B1 | USE OF 1-THIA-DIBENZO E,H AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS | GLAXOSMITHKLINE ZAGREB (HR) | 2007-09-12 | — | — | EP | disclosed |
| US-20070078123-A1 | 1-Thia-3-aza-dibenzo[e,h]azulenes for the treatment of central nervous system diseases and disorders | PILVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2007-04-05 | — | — | US | disclosed |
| EP-1684751-A1 | USE OF 1-THIA-DIBENZO E,H AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005049020-A1 | USE OF 1-THIA-DIBENZO[E,H]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078123-A1 | 1-Thia-3-aza-dibenzo[e,h]azulenes for the treatment of central nervous system diseases and disorders | DBH, BCHE, MAOB | HRH3 141/4885CACNA1H 358/4885CACNA1B 821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.