Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | CDC25B | P30305 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2433083 | 0.80 | PTPN1 (0.38) | PTPN1MEN1KMT2ANR4A1NR4A2 | |
| SCHEMBL2435108 | 0.76 | PTPN1 (0.49) | PTPN1ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL2435235 | 0.75 | PTPN1 (0.48) | PTPN1ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL2439081 | 0.67 | PTPN1 (0.47) | PTPN1ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL2433575 | 0.67 | PTPN1 (0.47) | PTPN1ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL3668537 | 0.67 | KDR (0.48) | PTPN1KDRAURKAMETTEK | |
| SCHEMBL344157 | 0.63 | PTPN1 (0.66) | PTPN1ALDH1A1MEN1KMT2ANR4A1 | |
| SCHEMBL31522164 | 0.63 | PTPN1 (0.66) | PTPN1ALDH1A1MEN1KMT2ANR4A1 | |
| SCHEMBL6916641 | 0.61 | PTPN1 (0.64) | PTPN1ALDH1A1MEN1KMT2ANR4A1 | |
| SCHEMBL6917255 | 0.61 | PTPN1 (0.64) | PTPN1ALDH1A1MEN1KMT2ANR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794149-A2 | BICYCLIC AMIDES AS KINASE INHIBITORS | Novartis AG (CH) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006059234-A2 | BICYCLIC AMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2006-06-08 | — | — | WO | disclosed |