Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 9/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | BTK | Q06187 | 3/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4870568 | 0.92 | KCNA5 (0.43) | KCNH2KCNA5JAK2CDK2CCNE1 | |
| SCHEMBL4868763 | 0.82 | KCNA5 (0.49) | KCNH2KCNA5JAK2CDK2TYK2 | |
| SCHEMBL4865901 | 0.81 | KCNH2 (0.49) | KCNH2KCNA5JAK2CDK2TYK2 | |
| SCHEMBL4871028 | 0.80 | AURKA (0.61) | KCNH2KCNA5LMNATSHRHTT | |
| SCHEMBL4866797 | 0.74 | KCNH2 (0.52) | KCNH2KCNA5JAK2PDE5ALMNA | |
| SCHEMBL4862922 | 0.70 | KCNH2 (0.39) | KCNH2KCNA5JAK2CDK2TYK2 | |
| SCHEMBL4867422 | 0.68 | KCNH2 (0.43) | KCNH2KCNA5JAK2CDK2TYK2 | |
| SCHEMBL4870563 | 0.66 | SLC11A2 (0.34) | LMNAKDM4EALDH1A1 | |
| SCHEMBL3385287 | 0.65 | PRKCI (0.51) | KCNH2KCNA5JAK2CDK2TYK2 | |
| SCHEMBL3382594 | 0.65 | KCNH2 (0.49) | KCNH2KCNA5JAK2CDK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758909-A1 | FURANOPYRIMIDINE COMPOUNDS EFFECTIVE AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005121149-A1 | FURANOPYRIMIDINE COMPOUNDS EFFECTIVE AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2005-12-22 | — | — | WO | disclosed |