Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.49 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.38 |
| ▸ | PLAU | P00749 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28216784 | 0.83 | STK17A (0.53) | STK17BSTK17AALDH1A1L3MBTL1ATM | |
| SCHEMBL12798437 | 0.82 | STK17A (0.47) | STK17BSTK17AALDH1A1L3MBTL1S100A9 | |
| SCHEMBL20980103 | 0.81 | POLB (0.41) | STK17BSTK17AMAPTPLAUALDH1A1 | |
| SCHEMBL21599136 | 0.81 | JAK3 (0.41) | MAPTPLAU | |
| SCHEMBL7491353 | 0.79 | MAPT (0.64) | STK17AMAPTL3MBTL1SIRT5PIN1 | |
| SCHEMBL21352288 | 0.76 | STK17A (0.63) | STK17BSTK17ASIRT5 | |
| SCHEMBL21352293 | 0.76 | STK17A (0.67) | STK17BSTK17ASIRT5 | |
| SCHEMBL14524671 | 0.76 | STK17B (0.47) | STK17BSTK17AALDH1A1L3MBTL1KDM4E | |
| SCHEMBL10229480 | 0.76 | STK17A (0.55) | STK17BSTK17AALDH1A1L3MBTL1SIRT5 | |
| SCHEMBL1938460 | 0.75 | STK17A (0.51) | STK17BSTK17AALDH1A1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831181-A2 | PYRIMIDINE INHIBITORS OF ERK PROTEIN KINASE AND USES THEREOF | Vertex Pharmaceuticals Incorporated (US) | 2007-09-12 | — | — | EP | disclosed |
| US-20060142572-A1 | Inhibitors of ERK protein kinase and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2006-06-29 | — | — | US | disclosed |
| WO-2006065820-A2 | PYRIMIDINE INHIBITORS OF ERK PROTEIN KINASE AND USES THEROF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142572-A1 | Inhibitors of ERK protein kinase and uses thereof | MAPK1, MAP3K1, MAP3K20 | STK17B 248/4885STK17A 199/4885MAPT 2660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.