Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PMP22 | Q01453 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 2/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | GRM8 | O00222 | 1/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1345201 | 1.00 | PMP22 (0.41) | PMP22NOS3NOS1NOS2GSR | |
| SCHEMBL20214841 | 0.90 | OTC (0.49) | PMP22NOS3NOS1NOS2GSR | |
| SCHEMBL13585341 | 0.82 | EPHX1 (0.49) | PMP22GSRSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL29533865 | 0.82 | PMP22 (0.43) | PMP22NOS3NOS1NOS2GSR | |
| SCHEMBL13585339 | 0.82 | EPHX1 (0.49) | PMP22GSRSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL4393876 | 0.82 | PMP22 (0.43) | PMP22NOS3NOS1NOS2GSR | |
| SCHEMBL1344672 | 0.81 | SLC1A2 (0.42) | PMP22NOS3NOS1NOS2GSR | |
| Nor-Noha SCHEMBL4097591 | 0.80 | GSR (0.42) | PMP22NOS3NOS1NOS2GSR | |
| Nor-Noha SCHEMBL14754841 | 0.80 | GSR (0.42) | PMP22NOS3NOS1NOS2GSR | |
| SCHEMBL15030158 | 0.78 | PMP22 (0.46) | PMP22NOS3NOS1NOS2GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828109-A2 | GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH | UCL Business PLC (GB) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006051314-A2 | GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH | UCL BUSINESS PLC (GB) | 2006-05-18 | — | — | WO | disclosed |