SCHEMBL5246783

SCHEMBL5246783

COC(=O)Oc1scc2c1-c1cc(Cl)ccc1Oc1ccccc1-2

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.38
MAPT P10636 4/20 0.37
MEN1 O00255 2/20 0.37
CYP1A2 P05177 2/20 0.37
CYP3A4 P08684 2/20 0.37
CYP2D6 P10635 2/20 0.37
PMP22 Q01453 2/20 0.37
KMT2A Q03164 2/20 0.37
ALDH1A1 P00352 1/20 0.37
ALOX15 P16050 1/20 0.37
CYP2C19 P33261 1/20 0.37
THPO P40225 1/20 0.37
HDAC3 O15379 1/20 0.36
TUBB4A P04350 1/20 0.36
TUBB P07437 1/20 0.36
TUBA3C P0DPH7 1/20 0.36
HDAC4 P56524 1/20 0.36
TUBA1B P68363 1/20 0.36
TUBA4A P68366 1/20 0.36
TUBB4B P68371 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5251613 0.96 MAPK1 (0.38) MAPK1MAPTMEN1CYP1A2CYP3A4
SCHEMBL4842030 0.82 PTPN1 (0.40) MAPK1MAPTALDH1A1LMNANPBWR1
SCHEMBL4843947 0.77 MAPK1 (0.40) MAPK1MAPTMEN1CYP1A2CYP3A4
SCHEMBL5253913 0.75 TYMS (0.41) MAPTMEN1CYP1A2CYP3A4PMP22
SCHEMBL4846600 0.75 MAPK1 (0.41) MAPK1MAPTMEN1CYP1A2CYP3A4
SCHEMBL4845574 0.70 MAPK1 (0.41) MAPK1MAPTMEN1CYP1A2CYP3A4
SCHEMBL4847727 0.70 ALDH1A1 (0.41) MAPK1MAPTMEN1CYP1A2CYP3A4
SCHEMBL4847452 0.70 ALDH1A1 (0.41) MAPK1MAPTMEN1CYP1A2CYP3A4
SCHEMBL10733451 0.68 MAPK1 (0.44) MAPK1MEN1CYP1A2CYP3A4CYP2D6
SCHEMBL4848841 0.67 MAPK1 (0.39) MAPK1MAPTCYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1684702-B1 USE OF 2-THIA-DIBENZO[E,H]AZULENES FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS GLAXOSMITHKLINE ZAGREB (HR) 2007-09-19 EP claimed
EP-1509530-B1 2-THIA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF PLIVA ISTRAZIVACKI INST D O O (HR) 2006-03-15 EP claimed