SCHEMBL5247397

SCHEMBL5247397

O=C1CCN(S(=O)(=O)c2ccccc2Cl)CC1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.59
CHRM4 P08173 2/20 0.54
TSHR P16473 2/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
FAAH O00519 5/20 0.51
MAPT P10636 1/20 0.50
MAPK1 P28482 1/20 0.50
CTSG P08311 1/20 0.49
CMA1 P23946 1/20 0.49
HDAC3 O15379 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10723724 0.88 CHRM4 (0.64) KMT2ACHRM4TSHRCYP3A4CYP2C9
SCHEMBL4555453 0.83 TSHR (0.78) KMT2ACHRM4TSHRCYP3A4CYP2C9
SCHEMBL31684034 0.83 TSHR (0.78) KMT2ACHRM4TSHRCYP3A4CYP2C9
SCHEMBL27974780 0.81 CHRM4 (0.54) KMT2ACHRM4TSHRCYP3A4CYP2C9
SCHEMBL654111 0.80 USP2 (0.66) KMT2ACHRM4TSHRCYP3A4CYP2C9
SCHEMBL19348478 0.80 KMT2A (0.67) KMT2ATSHRCYP3A4CYP2C9CYP2C19
SCHEMBL2954361 0.80 POLB (0.67) KMT2ACHRM4TSHRCYP3A4CYP2C9
SCHEMBL12656055 0.80 CYP3A4 (0.52) KMT2ATSHRCYP3A4CYP2C9CYP2C19
SCHEMBL7130175 0.80 POLB (0.61) KMT2ACHRM4FAAHALDH1A1
SCHEMBL3247291 0.80 CNR1 (0.56) KMT2ACHRM4TSHRCYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1866298-A2 HYDROXYSTEROID DEHYDROGENASE INHIBITORS Takeda San Diego, Inc. (US) 2007-12-19 EP disclosed
WO-2006105127-A2 HYDROXYSTEROID DEHYDROGENASE INHIBITORS TAKEDA SAN DIEGO, INC. (US) 2006-10-05 WO disclosed