Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.74 |
| ▸ | USP2 | O75604 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5248148 | 0.85 | HPGD (0.74) | HPGDALDH1A1USP2POLBMAPT | |
| SCHEMBL28741579 | 0.84 | HPGD (0.72) | HPGDALDH1A1USP2POLBMAPT | |
| SCHEMBL1709325 | 0.84 | HPGD (0.72) | HPGDALDH1A1USP2POLBMAPT | |
| SCHEMBL4091917 | 0.84 | HPGD (0.72) | HPGDALDH1A1USP2POLBMAPT | |
| SCHEMBL13438260 | 0.84 | USP2 (0.93) | HPGDALDH1A1USP2POLBMAPT | |
| SCHEMBL18175783 | 0.83 | POLB (0.68) | HPGDALDH1A1USP2POLBMAPT | |
| SCHEMBL18415485 | 0.82 | POLB (0.72) | HPGDALDH1A1USP2POLBMAPT | |
| SCHEMBL14142610 | 0.82 | LMNA (0.80) | HPGDALDH1A1USP2POLBMAPT | |
| SCHEMBL3561734 | 0.81 | POLB (0.70) | HPGDALDH1A1USP2POLBMAPT | |
| SCHEMBL8269659 | 0.81 | USP2 (0.76) | HPGDALDH1A1USP2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1855672-A1 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006104646-A1 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-05 | — | — | WO | claimed |
| EP-1855672-A1 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006104646-A1 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-05 | — | — | WO | disclosed |