Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 18/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5252182 | 0.91 | CHEK2 (0.57) | CHEK2 | |
| SCHEMBL3916642 | 0.87 | CHEK2 (0.77) | CHEK2 | |
| SCHEMBL5252282 | 0.80 | CHEK2 (0.67) | CHEK2TP53MAPTSMN1; SMN2HSPD1 | |
| SCHEMBL5250698 | 0.78 | CHEK2 (0.58) | CHEK2TP53 | |
| SCHEMBL3915829 | 0.78 | CHEK2 (0.76) | CHEK2 | |
| SCHEMBL5252823 | 0.77 | CHEK2 (0.57) | CHEK2 | |
| SCHEMBL5251652 | 0.77 | CHEK2 (0.67) | CHEK2TP53MAPTSMN1; SMN2HSPD1 | |
| SCHEMBL5248310 | 0.74 | CHEK2 (0.61) | CHEK2TP53MAPTSMN1; SMN2 | |
| SCHEMBL5254939 | 0.73 | CHEK2 (0.60) | CHEK2 | |
| SCHEMBL3928053 | 0.72 | CHEK2 (0.77) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435947-B1 | 2-PHENYL BENZIMIDAZOLES AND IMIDAZO-¬4,5|-PYRIDINES AS CDS1/CHK2-INHIBITORS AND ADJUVANTS TO CHEMOTHERAPY OR RADIATION THERAPY IN THE TREATMENT OF CANCER | ORTHO MCNEIL PHARM INC (US) | 2007-08-15 | — | — | EP | claimed |