Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 18/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5248602 | 0.91 | CHEK2 (0.58) | CHEK2 | |
| SCHEMBL3915829 | 0.86 | CHEK2 (0.76) | CHEK2MEN1THRBKMT2A | |
| SCHEMBL5250698 | 0.85 | CHEK2 (0.58) | CHEK2MEN1THRBKMT2AKDR | |
| SCHEMBL5252823 | 0.84 | CHEK2 (0.57) | CHEK2MEN1THRBKMT2ADGAT1 | |
| SCHEMBL5248310 | 0.82 | CHEK2 (0.61) | CHEK2MEN1THRBKMT2AKDR | |
| SCHEMBL5252672 | 0.80 | CHEK2 (0.66) | CHEK2MEN1THRBKMT2A | |
| SCHEMBL3916642 | 0.78 | CHEK2 (0.77) | CHEK2 | |
| SCHEMBL3928053 | 0.75 | CHEK2 (0.77) | CHEK2MEN1THRBKMT2A | |
| SCHEMBL5298124 | 0.73 | CHEK2 (0.65) | CHEK2MEN1THRBKMT2ADGAT1 | |
| SCHEMBL5251652 | 0.73 | CHEK2 (0.67) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435947-B1 | 2-PHENYL BENZIMIDAZOLES AND IMIDAZO-¬4,5|-PYRIDINES AS CDS1/CHK2-INHIBITORS AND ADJUVANTS TO CHEMOTHERAPY OR RADIATION THERAPY IN THE TREATMENT OF CANCER | ORTHO MCNEIL PHARM INC (US) | 2007-08-15 | — | — | EP | claimed |