Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5248956 | 1.00 | KDM4E (0.48) | KDM4EALDH1A1GAAMAPK1HDAC3 | |
| SCHEMBL13755354 | 0.81 | KDM4E (0.44) | KDM4EALDH1A1GAAMAPK1HDAC3 | |
| SCHEMBL3549948 | 0.80 | KDM4E (0.49) | KDM4EALDH1A1GAAMAPK1HDAC3 | |
| SCHEMBL3549945 | 0.80 | KDM4E (0.49) | KDM4EALDH1A1GAAMAPK1HDAC3 | |
| SCHEMBL3543861 | 0.79 | HDAC8 (0.56) | KDM4EALDH1A1GAAMAPK1HDAC3 | |
| SCHEMBL3541484 | 0.78 | NPC1 (0.53) | KDM4EALDH1A1GAAMAPK1HDAC3 | |
| SCHEMBL3541478 | 0.78 | NPC1 (0.53) | KDM4EALDH1A1GAAMAPK1HDAC3 | |
| SCHEMBL5438599 | 0.77 | ALDH1A1 (0.45) | ALDH1A1SLC18A3MAPTLMNAMAOA | |
| SCHEMBL13008026 | 0.77 | KDM4E (0.46) | KDM4EALDH1A1GAAMAPK1HDAC3 | |
| SCHEMBL14199019 | 0.77 | KDM4E (0.46) | KDM4EALDH1A1GAAMAPK1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833806-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006064189-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |