Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 6/20 | 0.47 |
| ▸ | RET | P07949 | 5/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ITK | Q08881 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1900577 | 0.75 | ITK (0.54) | GSK3BKDRRETITKNPC1 | |
| SCHEMBL5247261 | 0.75 | GSK3B (0.49) | GSK3BKDRRETSRCABL1 | |
| SCHEMBL21945267 | 0.73 | ITK (0.49) | GSK3BKDRRETSRCABL1 | |
| SCHEMBL7027575 | 0.72 | ITK (0.48) | GSK3BKDRRETSRCABL1 | |
| SCHEMBL5179280 | 0.72 | ITK (0.61) | GSK3BKDRRETITKNPC1 | |
| SCHEMBL1901060 | 0.72 | GSK3B (0.56) | GSK3BKDRRETSRCABL1 | |
| SCHEMBL2876288 | 0.71 | ITK (0.60) | GSK3BKDRRETSRCABL1 | |
| SCHEMBL14764843 | 0.71 | GSK3B (0.51) | GSK3BKDRRETSRCABL1 | |
| SCHEMBL19476287 | 0.70 | RET (0.56) | GSK3BKDRRETSRCABL1 | |
| SCHEMBL7027580 | 0.70 | MAPK14 (0.47) | GSK3BKDRRETSRCABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848506-A2 | PYRIMIDINE-FUSED DIAZEPINE DERIVATIVES AND INDOLE-FUSED PTERIDINES | Attenuon, LLC (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006089298-A2 | PYRIMIDINE-FUSED DIAZEPINE DERIVATIVES AND INDOLE-FUSED PTERIDINES | ATTENUON, LLC (US) | 2006-08-24 | — | — | WO | disclosed |