Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.62 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.62 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.62 |
| ▸ | MAOB | P27338 | 5/20 | 0.59 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.55 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.55 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5799798 | 0.85 | PARP10 (0.70) | NR4A2MAOBSMN1; SMN2PARP10SRD5A2 | |
| SCHEMBL5746820 | 0.84 | MAOB (0.68) | KMT2AMEN1NR4A2SPHK2SPHK1 | |
| SCHEMBL28647670 | 0.84 | MEN1 (0.56) | KMT2AMEN1NR4A2SPHK2SPHK1 | |
| SCHEMBL12635062 | 0.83 | NR4A2 (0.69) | KMT2AMEN1NR4A2SPHK2SPHK1 | |
| SCHEMBL1268719 | 0.82 | MAOB (0.81) | KMT2AMEN1NR4A2MAOBSMPD1 | |
| SCHEMBL9078701 | 0.81 | KMT2A (0.56) | KMT2AMEN1NR4A2SPHK2SPHK1 | |
| SCHEMBL1387246 | 0.81 | NR4A2 (0.77) | KMT2AMEN1NR4A2SPHK2MAOB | |
| SCHEMBL2848980 | 0.81 | NR4A2 (0.62) | KMT2ANR4A2SPHK2SPHK1MAOB | |
| SCHEMBL2774848 | 0.80 | NR4A2 (0.66) | KMT2AMEN1NR4A2SPHK2SPHK1 | |
| Hydrochloric Acid SCHEMBL27603151 | 0.79 | NR4A2 (0.74) | KMT2AMEN1NR4A2SPHK2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023222124-A1 | 5,6-DIHYDRO-1,2,4-TRIAZINE COMPOUND AND PHARMACEUTICAL USE THEREOF AS GLP-1 RECEPTOR AGONIST | 中国科学院上海药物研究所 | 2023-11-23 | — | — | WO | disclosed |
| CN-115521297-A | 5,6-dihydro-1,2,4-triazines and their pharmaceutical use as GLP-1 receptor agonists | 中国科学院上海药物研究所 | 2022-12-27 | — | — | CN | disclosed |
| EP-1831164-A1 | HETEROCYCLIC COMPOUNDS AS CCR2B ANTAGONISTS | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006067401-A1 | HETEROCYCLIC COMPOUNDS AS CCR2B ANTAGONISTS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |