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Acetamide

Acetamide

SCHEMBL5249774

CC(N)=O.CN(C)CCCCNc1ncc(C#Cc2cccc(NC(=O)Nc3cc(C(C)(C)C)on3)c2)cn1

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.46
▸ NPC1 O15118 1/20 0.46
▸ RAB9A P51151 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ RET P07949 2/20 0.44
▸ FLT3 P36888 5/20 0.43
▸ BRAF P15056 7/20 0.43
▸ RAF1 P04049 6/20 0.42
▸ MAPK14 Q16539 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4717345 0.97 MEN1 (0.49) MEN1NPC1RAB9AKMT2ARET
SCHEMBL4715279 0.94 MEN1 (0.50) MEN1NPC1RAB9AKMT2ARET
SCHEMBL4717473 0.92 MEN1 (0.51) MEN1NPC1RAB9AKMT2ARET
SCHEMBL4717756 0.90 MEN1 (0.50) MEN1NPC1RAB9AKMT2ARET
SCHEMBL4715102 0.89 MEN1 (0.51) MEN1NPC1RAB9AKMT2ARET
SCHEMBL4716485 0.87 MEN1 (0.53) MEN1NPC1RAB9AKMT2ARET
SCHEMBL4715826 0.86 MEN1 (0.53) MEN1NPC1RAB9AKMT2ARET
SCHEMBL4718886 0.85 RAF1 (0.50) MEN1NPC1RAB9AKMT2AFLT3
SCHEMBL5249787 0.85 BRAF (0.34) MEN1NPC1RAB9AKMT2ARET
SCHEMBL4715819 0.85 MEN1 (0.48) MEN1NPC1RAB9AKMT2ARET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1737463-A1 PYRIMIDINES WITH TIE2 (TEK) ACTIVITY AstraZeneca AB (SE) 2007-01-03 — — EP disclosed
WO-2005060970-A1 PYRIMIDINES WITH TIE2 (TEK) ACTIVITY ASTRAZENECA AB (SE) 2005-07-07 — — WO disclosed