Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.34 |
| ▸ | FLT3 | P36888 | 4/20 | 0.34 |
| ▸ | RET | P07949 | 3/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718430 | 0.88 | LCK (0.41) | BRAFFLT3RETMEN1NPC1 | |
| Acetamide SCHEMBL5249774 | 0.85 | MEN1 (0.46) | BRAFFLT3RETMEN1NPC1 | |
| SCHEMBL4717345 | 0.84 | MEN1 (0.49) | BRAFFLT3RETMEN1NPC1 | |
| SCHEMBL4715279 | 0.82 | MEN1 (0.50) | BRAFFLT3RETMEN1NPC1 | |
| SCHEMBL4717473 | 0.80 | MEN1 (0.51) | BRAFFLT3RETMEN1NPC1 | |
| SCHEMBL4717609 | 0.77 | BRAF (0.41) | BRAFLCK | |
| SCHEMBL4717756 | 0.77 | MEN1 (0.50) | BRAFFLT3RETMEN1NPC1 | |
| SCHEMBL4719952 | 0.77 | BRAF (0.44) | BRAFFGFR1LCK | |
| SCHEMBL4715102 | 0.76 | MEN1 (0.51) | BRAFFLT3RETMEN1NPC1 | |
| SCHEMBL4717232 | 0.75 | SLC2A1 (0.46) | BRAFFLT3SYKKDRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737463-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | AstraZeneca AB (SE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005060970-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |