Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.64 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.57 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.57 |
| ▸ | NTRK3 | Q16288 | 5/20 | 0.57 |
| ▸ | KDR | P35968 | 8/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.49 |
| ▸ | CSF1R | P07333 | 3/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.49 |
| ▸ | KIT | P10721 | 3/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.49 |
| ▸ | LCK | P06239 | 3/20 | 0.49 |
| ▸ | PLK4 | O00444 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29683745 | 1.00 | CHEK1 (0.64) | CHEK1NTRK1NTRK2NTRK3KDR | |
| SCHEMBL30236917 | 1.00 | CHEK1 (0.64) | CHEK1NTRK1NTRK2NTRK3KDR | |
| SCHEMBL5498220 | 0.82 | KDR (0.69) | CHEK1NTRK1NTRK2NTRK3KDR | |
| SCHEMBL14539159 | 0.82 | CHEK1 (0.67) | CHEK1NTRK1NTRK2NTRK3KDR | |
| SCHEMBL29531075 | 0.82 | CHEK1 (0.67) | CHEK1NTRK1NTRK2NTRK3KDR | |
| SCHEMBL28884515 | 0.82 | CHEK1 (0.67) | CHEK1NTRK1NTRK2NTRK3KDR | |
| SCHEMBL28884514 | 0.82 | CHEK1 (0.67) | CHEK1NTRK1NTRK2NTRK3KDR | |
| SCHEMBL22099881 | 0.82 | NTRK3 (0.60) | CHEK1NTRK1NTRK2NTRK3KDR | |
| SCHEMBL22099879 | 0.82 | NTRK3 (0.60) | CHEK1NTRK1NTRK2NTRK3KDR | |
| SCHEMBL5498217 | 0.82 | CHEK1 (0.67) | CHEK1NTRK1NTRK2NTRK3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1614683-B1 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | AGOURON PHARMA (US) | 2007-11-21 | — | — | EP | disclosed |